Synergistic activation of transcription by bacteriophage lambda cI protein and E. coli cAMP receptor protein.

Synergistic activation of transcription by bacteriophage lambda cI protein and E. coli cAMP receptor protein. Research Abstract Details 

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Synergistic activation of transcription by bacteriophage lambda cI protein and E. coli cAMP receptor protein. Abstract Text:

Two heterologous prokaryotic activators, the bacteriophage lambda cI protein (lambda cI) and the Escherichia coli cyclic AMP receptor protein (CRP), were shown to activate transcription synergistically from an artificial promoter bearing binding sites for both proteins. The synergy depends on a functional activation (positive control) surface on each activator. These results imply that both proteins interact directly with RNA polymerase and thus suggest a precise mechanism for transcriptional synergy: the interaction of two activators with two distinct surfaces of RNA polymerase.

Synergistic activation of transcription by bacteriophage lambda cI protein and E. coli cAMP receptor protein. Publishing Authors By Initials

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Synergistic activation of transcription by bacteriophage lambda cI protein and E. coli cAMP receptor protein. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Science (New York, N.Y.)

VOLUME: 265

Page Numbers: 1863-6

Journal Abbreviation: Science

ISSN: 0036-8075

DAY: 23

MONTH: Sep

YEAR: 1994

Synergistic activation of transcription by bacteriophage lambda cI protein and E. coli cAMP receptor protein. Information

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LANGUAGE: eng

NlmUniqueID: 404511

Synergistic activation of transcription by bacteriophage lambda cI protein and E. coli cAMP receptor protein. Keywords Mesh Terms:

KEYWORDS: Viral Regulatory and Accessory Proteins

MESH TERMS: metabolism

Chemical & Substance for Abstract: Synergistic activation of transcription by bacteriophage lambda cI protein and E. coli cAMP receptor protein. Information

Substance Name: DNA-Directed RNA Polymerases

Registry Number: EC 2.7.7.6

Grant and Affiliation Information for Synergistic activation of transcription by bacteriophage lambda cI protein and E. coli cAMP receptor protein.

AFFILIATION: Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115.

Country: UNITED STATES

AGENCY: United States NIGMS

GRANT: GM44025

ACRONYM: GM

MEDLINETA: Science

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