Synergistic actions of enalapril and tempol during chronic angiotensin II-induced hypertension.

Synergistic actions of enalapril and tempol during chronic angiotensin II-induced hypertension. Research Abstract Details 

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Synergistic actions of enalapril and tempol during chronic angiotensin II-induced hypertension. Abstract Text:

Ahmed A Elmarakby,Jan M Williams,John D Imig,Jennifer S Pollock,David M Pollock,

Experiments were designed to test the hypothesis that antioxidant treatment would increase the anti-hypertensive actions of endogenous kinins during angiotensin converting enzyme (ACE) inhibition. Four groups of rats, all given angiotensin II (Ang II) for 2 weeks, were studied: 1) control, 2) enalapril, 3) tempol or 4) both tempol and enalapril. Ang II significantly increased systolic blood pressure (BP) when compared with the baseline (170+/-8 vs. 128+/-4 mm Hg, P<0.05). Neither enalapril nor tempol alone was able to attenuate the elevation in BP (165+/-7 and 164+/-6 mm Hg, respectively). In contrast, combined administration of tempol and enalapril prevented the increase in BP (137+/-5 mm Hg). Plasma 8-isoprostane increased in Ang II-infused rats when compared with control untreated rats (69+/-14 vs. 23+/-0.5 pg/ml, P<0.05). Tempol alone or tempol plus enalapril significantly attenuated the increase in plasma 8-isoprostane (29+/-6 and 34+/-7 pg/ml, respectively). In additional experiments, we used the bradykinin B(2) antagonist, icatibant to determine if increased B(2) receptor contributes to the anti-hypertensive effect of combined tempol and enalapril in Ang II-infused rats. Icatibant decreased the ability of this combination to lower arterial pressure. Additionally, a significant increase in B(1) receptor protein expression in renal cortex of Ang II-infused rats was observed compared to control suggesting that bradykinin receptor activation could account for the effect of enalapril to enhance the actions of tempol. These data support the hypothesis that combined reduction of superoxide along with enhanced endogenous kinins may facilitate blood pressure lowering in Ang II hypertension.

Synergistic actions of enalapril and tempol during chronic angiotensin II-induced hypertension. Publishing Authors By Initials

AA Elmarakby,JM Williams,JD Imig,JS Pollock,DM Pollock,

For similar natural sciences: time: time factors research abstracts see: natural sciences: time: time factors research

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Synergistic actions of enalapril and tempol during chronic angiotensin II-induced hypertension. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Vascular pharmacology

VOLUME: 46

Page Numbers: 144-51

Journal Abbreviation: Vascul. Pharmacol.

ISSN: 1537-1891

DAY: 26

MONTH: 09

YEAR: 2006

Synergistic actions of enalapril and tempol during chronic angiotensin II-induced hypertension. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101130615

Synergistic actions of enalapril and tempol during chronic angiotensin II-induced hypertension. Keywords Mesh Terms:

KEYWORDS: Time Factors

MESH TERMS: metabolism

Chemical & Substance for Abstract: Synergistic actions of enalapril and tempol during chronic angiotensin II-induced hypertension. Information

Substance Name: Hydrogen Peroxide

Registry Number: 7722-84-1

Grant and Affiliation Information for Synergistic actions of enalapril and tempol during chronic angiotensin II-induced hypertension.

AFFILIATION: Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, Georgia 30912, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: HL74167

ACRONYM: HL

MEDLINETA: Vascul Pharmacol

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