Synergism in the repression of COX-2- and TNFalpha-induction in platelet activating factor-stressed human neural cells.

Synergism in the repression of COX-2- and TNFalpha-induction in platelet activating factor-stressed human neural cells. Research Abstract Details 

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Synergism in the repression of COX-2- and TNFalpha-induction in platelet activating factor-stressed human neural cells. Abstract Text:

Anja Boetkjaer,Merete Boedker,Jian-Guo Cui,Yuhai Zhao,Walter J Lukiw,Anja Boetkjaer,Merete Boedker,Jian-Guo Cui,Yuhai Zhao,Walter J Lukiw,

Platelet activating factor (PAF; beta-acetyl-gamma-O-hexadecyl-l-alpha-phosphatidylcholine) triggers a rapid pro-inflammatory gene expression program in primary cultures of human neural (HN) cells. Two genes and gene products consistently induced after PAF treatment are the cytosoluble prostaglandin synthase cycloooxygenase-2 (COX-2) and the pro-apoptotic tumor necrosis factor alpha (TNFalpha). Both of these mediators are associated with the activation of inflammatory signaling, neural cell dysfunction, apoptosis and brain cell death, and both have been found to be up-regulated after brain injury in vivo. In this study we investigated the effects of the non-halogenated synthetic glucocorticoid budesonide epimer R (BUDeR), the novel PAF antagonist LAU-0901, and the electron spin trap and free radical scavenger phenyl butyl nitrone (PBN), upon early COX-2 and TNFalpha gene activation and prostaglandin E(2) (PGE(2)) release in PAF-stressed primary HN cells. The data indicate that these three biochemically unrelated classes of inflammatory repressors act synergistically in modulating PAF-induced up-regulation of COX-2, TNFalpha, and PGE(2) by quenching oxidative stress or inflammatory signaling, resulting in increased HN cell survival. These, or analogous classes of compounds, may be useful in the design of more effective combinatorial pharmacotherapeutic strategies in the treatment of complex neuro-inflammatory disorders.

Synergism in the repression of COX-2- and TNFalpha-induction in platelet activating factor-stressed human neural cells. Publishing Authors By Initials

A Boetkjaer,M Boedker,JG Cui,Y Zhao,WJ Lukiw,A Boetkjaer,M Boedker,JG Cui,Y Zhao,WJ Lukiw,

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Synergism in the repression of COX-2- and TNFalpha-induction in platelet activating factor-stressed human neural cells. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Neuroscience letters

VOLUME: 426

Page Numbers: 59-63

Journal Abbreviation: Neurosci. Lett.

ISSN: 0304-3940

DAY: 31

MONTH: 08

YEAR: 2007

Synergism in the repression of COX-2- and TNFalpha-induction in platelet activating factor-stressed human neural cells. Information

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LANGUAGE: eng

NlmUniqueID: 7600130

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Grant and Affiliation Information for Synergism in the repression of COX-2- and TNFalpha-induction in platelet activating factor-stressed human neural cells.

AFFILIATION: The Danish University of Pharmaceutical Sciences, Universitetsparken 2, DK 2100 Copenhagen, Denmark.

Country: Ireland

AGENCY: United States NIA

GRANT: R01 AG018031-05S1

ACRONYM: AG

MEDLINETA: Neurosci Lett

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