Synergism between NF-kappa B1/p50 and Notch2 during the development of marginal zone B lymphocytes.

Synergism between NF-kappa B1/p50 and Notch2 during the development of marginal zone B lymphocytes. Research Abstract Details 

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Synergism between NF-kappa B1/p50 and Notch2 during the development of marginal zone B lymphocytes. Abstract Text:

Stewart T Moran,Annaiah Cariappa,Haoyuan Liu,Beth Muir,Dennis Sgroi,Cristian Boboila,Shiv Pillai,

NF-kappaB1 and Notch2 are both required for the development of marginal zone (MZ) B cells. Analysis of B lymphocyte development in mice that are doubly heterozygous at the Notch2 and NF-kappaB1 loci revealed synergism between Notch2 and NF-kappaB1 during MZ B cell development. Two known transcriptional targets of the Notch pathway, Hes-5 and Deltex-1, were found to be preferentially expressed in MZ B cells and regulated by NF-kappaB1. These studies provide in vivo evidence for a genetic interaction between the Notch and NF-kappaB pathways.

Synergism between NF-kappa B1/p50 and Notch2 during the development of marginal zone B lymphocytes. Publishing Authors By Initials

ST Moran,A Cariappa,H Liu,B Muir,D Sgroi,C Boboila,S Pillai,

For similar tissues: lymphoid tissue: spleen research abstracts see: tissues: lymphoid tissue: spleen research

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Synergism between NF-kappa B1/p50 and Notch2 during the development of marginal zone B lymphocytes. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of immunology (Baltimore, Md. : 1950)

VOLUME: 179

Page Numbers: 195-200

Journal Abbreviation: J. Immunol.

ISSN: 0022-1767

DAY: 1

MONTH: Jul

YEAR: 2007

Synergism between NF-kappa B1/p50 and Notch2 during the development of marginal zone B lymphocytes. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985117

Synergism between NF-kappa B1/p50 and Notch2 during the development of marginal zone B lymphocytes. Keywords Mesh Terms:

KEYWORDS: Spleen

MESH TERMS: pathology

Chemical & Substance for Abstract: Synergism between NF-kappa B1/p50 and Notch2 during the development of marginal zone B lymphocytes. Information

Substance Name: Protein-Tyrosine Kinases

Registry Number: EC 2.7.1.112

Grant and Affiliation Information for Synergism between NF-kappa B1/p50 and Notch2 during the development of marginal zone B lymphocytes.

AFFILIATION: Cancer Center, Massachusetts General Hospital, Harvard Medical Scool, 13th Street, Charlestown, MA 02129, USA.

Country: United States

AGENCY: United States NCI

GRANT: CA 102973

ACRONYM: CA

MEDLINETA: J Immunol

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