Synchronization of ventral-group, bulbospinal inspiratory neurons in the decerebrate rat.

Synchronization of ventral-group, bulbospinal inspiratory neurons in the decerebrate rat. Research Abstract Details 

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Synchronization of ventral-group, bulbospinal inspiratory neurons in the decerebrate rat. Abstract Text:

G F Tian,J Duffin,

We examined the synaptic connections between ventral-group, bulbospinal inspiratory neurons in 27 vagotomized, paralyzed, ventilated, and decerebrated rats using cross-correlation and spike-triggered averaging of intracellular potentials. The neurons were recorded in the medulla about the level of the obex and identified by their inspiratory firing pattern and antidromic activation from the spinal cord at C7. Whole C5 phrenic nerve recordings were made using bipolar electrodes from the central cut ends of the nerve. Most (108/137, 79%) inspiratory neurons discharged only during inspiration but some (29/137, 21%) also discharged during early expiration. Their intracellular membrane potentials displayed a pattern of depolarization during inspiration, repolarization during early expiration, and hyperpolarization during late expiration. Intracellular chloride iontophoresis changed the inspiratory membrane potential trajectories from augmenting to decrementing in 11 of 19 neurons tested (58%), and demonstrated the presence of both early-decrementing and late-augmenting waves of inhibitory postsynaptic potentials during expiration in 11 of 19 neurons tested (58%). Cross-correlation histograms were computed between pairs of extracellularly recorded neurons to detect short time scale synchronizations indicative of synaptic connections (26 ipsilateral; 23 contralateral). While none of the cross-correlation histograms for contralateral pairs showed peaks, most (23, 88%) of those for ipsilateral pairs showed peaks (mean half-amplitude width +/- SD = 1.3 +/- 0.4 ms) at time zero suggestive of common activation. Some of the latter (6, 23%) showed troughs superimposed on the central peaks (mean half-amplitude width +/- SD = 0.9 +/- 0.2 ms) at short latencies (mean latency +/- SD = 1.8 +/- 1.9 ms) suggestive of inhibition; others (8, 31%) had asymmetrical central peaks and two had bilateral peaks suggesting more complex interconnections. Averages of intracellular membrane potentials of inspiratory neurons (n = 24), triggered by action potentials of a nearby extracellularly recorded inspiratory neuron, were computed to detect synchronized postsynaptic potentials. Over half (16, 67%) showed postsynaptic potentials (mean amplitude +/- SD = 201 +/- 176 microV; mean half-amplitude width +/- SD = 2.3 +/- 0.8 ms) confirming the cross-correlation findings of common excitation. We conclude that in decerebrated rats, ventral-group inspiratory neurons projecting to the C7 spinal segment share powerful, ipsilaterally distributed excitatory inputs which enhance their synchronous activity during inspiration. They also receive inhibition during inspiration and early-decrementing and late-augmenting inhibitory inputs during expiration.

Synchronization of ventral-group, bulbospinal inspiratory neurons in the decerebrate rat. Publishing Authors By Initials

GF Tian,J Duffin,

For similar nervous system: central nervous system: spinal cord research abstracts see: nervous system: central nervous system: spinal cord research

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Synchronization of ventral-group, bulbospinal inspiratory neurons in the decerebrate rat. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Experimental brain research. Experimentelle Hirnfo

VOLUME: 117

Page Numbers: 479-87

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ISSN: 0014-4819

DAY: 15

MONTH: Dec

YEAR: 1997

Synchronization of ventral-group, bulbospinal inspiratory neurons in the decerebrate rat. Information

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LANGUAGE: eng

NlmUniqueID: 43312

Synchronization of ventral-group, bulbospinal inspiratory neurons in the decerebrate rat. Keywords Mesh Terms:

KEYWORDS: Spinal Cord

MESH TERMS: physiology

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Grant and Affiliation Information for Synchronization of ventral-group, bulbospinal inspiratory neurons in the decerebrate rat.

AFFILIATION: Department of Anaesthesia, University of Toronto, Ontario, Canada.

Country: GERMANY

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MEDLINETA: Exp Brain Res

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