Synaptic plasticity induced in single neurones of the primary somatosensory cortex in vivo.

Synaptic plasticity induced in single neurones of the primary somatosensory cortex in vivo. Research Abstract Details 

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Synaptic plasticity induced in single neurones of the primary somatosensory cortex in vivo. Abstract Text:

P M Cahusac,

Experiments carried out in urethane-anaesthetized rats in which single neurones were recorded extracellularly from primary somatosensory (SI) cortex employed a procedure in which one of two vibrissal inputs was temporally paired with iontophoretic applications of glutamate. Following the pairing procedure. 31% of 49 neurones studied displayed some form of synaptic plasticity, in that responses to one or both vibrissal stimuli were altered. Homosynaptic potentiation occurred in 4 neurones, and these were recorded in layers II/III only. Homosynaptic depression occurred in 6 neurones and were mainly recorded in layer IV. Heterosynaptic depression was observed in 3 neurones. Non-selective depression was observed in 2 neurones. The duration of the induced plastic changes typically exceeded 15 min, and often lasted as long as stable recordings continued. The results from experiments in which repeated glutamate applications were given alone (without synaptic input) confirmed that the non-selective changes were due to repeated glutamate applications and not the temporal pairing with synaptic responses per se. Dual recordings confirmed that plasticity was restricted to the neurone at which pairings were made, and (at the other neurone) that synaptic responses remained stable over the course of study. In some neurones homosynaptic potentiation and depression were shown to occur to the early response component (< 10 ms), suggesting that direct thalamocortical synapses are modifiable.

Synaptic plasticity induced in single neurones of the primary somatosensory cortex in vivo. Publishing Authors By Initials

PM Cahusac,

For similar animal structures: vibrissae research abstracts see: animal structures: vibrissae research

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Synaptic plasticity induced in single neurones of the primary somatosensory cortex in vivo. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Experimental brain research. Experimentelle Hirnfo

VOLUME: 107

Page Numbers: 241-53

Journal Abbreviation:

ISSN: 0014-4819

DAY: 15

MONTH: 02

YEAR: 1995

Synaptic plasticity induced in single neurones of the primary somatosensory cortex in vivo. Information

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LANGUAGE: eng

NlmUniqueID: 43312

Synaptic plasticity induced in single neurones of the primary somatosensory cortex in vivo. Keywords Mesh Terms:

KEYWORDS: Vibrissae

MESH TERMS: innervation

Chemical & Substance for Abstract: Synaptic plasticity induced in single neurones of the primary somatosensory cortex in vivo. Information

Substance Name: Glutamic Acid

Registry Number: 56-86-0

Grant and Affiliation Information for Synaptic plasticity induced in single neurones of the primary somatosensory cortex in vivo.

AFFILIATION: Department of Psychology, University of Stirling, Scotland, UK.

Country: GERMANY

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MEDLINETA: Exp Brain Res

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