Synaptic interaction between ghrelin- and ghrelin-containing neurons in the rat hypothalamus.

Synaptic interaction between ghrelin- and ghrelin-containing neurons in the rat hypothalamus. Research Abstract Details 

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Synaptic interaction between ghrelin- and ghrelin-containing neurons in the rat hypothalamus. Abstract Text:

Yasunori Hori,Haruaki Kageyama,Jian-Lian Guan,Daisuke Kohno,Toshihiko Yada,Fumiko Takenoya,Naoko Nonaka,Kenji Kangawa,Seiji Shioda,Takemi Yoshida,

Synaptic relationships between ghrelin-like immunoreactive axon terminals and other neurons in the hypothalamic arcuate nucleus (ARC) were studied using immunostaining methods at the light and electron microscope levels. Many ghrelin-like immunoreactive axon terminals were found to be in apposition to ghrelin-like immunoreactive neurons at the light microscopic level. At the electron microscopic level, ghrelin-like immunoreactive axon terminals were found to make synapses on ghrelin-like immunoreactive cell bodies and dendrites in the ARC. While the axo-dendritic synapses between ghrelin- and ghrelin-like immunoreactive neurons were mostly the asymmetric type, the axo-somatic synapses were both asymmetric and symmetric type of synapses. Ghrelin at 10(-10) M increased cytosolic Ca(2+) concentration ([Ca(2+)](i)) in the neurons isolated from the ARC, some of which were immunocytochemically identified as ghrelin-positive. Ghrelin at 10(-10) M also increased [Ca(2+)](i) in 12% of ghrelin-like immunoreactive neurons in the ARC. These findings suggest that ghrelin serves as a transmitter and/or modulator that stimulates [Ca(2+)](i) signaling in ghrelin neurons of the ARC, which may participate in the orexigenic action of ghrelin. Our data suggests a possibility of existing a novel circuit implicating regulation of feeding and/or energy metabolism.

Synaptic interaction between ghrelin- and ghrelin-containing neurons in the rat hypothalamus. Publishing Authors By Initials

Y Hori,H Kageyama,JL Guan,D Kohno,T Yada,F Takenoya,N Nonaka,K Kangawa,S Shioda,T Yoshida,

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Synaptic interaction between ghrelin- and ghrelin-containing neurons in the rat hypothalamus. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Regulatory peptides

VOLUME: 145

Page Numbers: 122-7

Journal Abbreviation: Regul. Pept.

ISSN: 0167-0115

DAY: 25

MONTH: 09

YEAR: 2007

Synaptic interaction between ghrelin- and ghrelin-containing neurons in the rat hypothalamus. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Synaptic interaction between ghrelin- and ghrelin-containing neurons in the rat hypothalamus.

AFFILIATION: Department of Biochemical Toxicology, School of Pharmaceutical Sciences, Showa University, Tokyo 142-8555, Japan; Department of Anatomy, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan.

Country: Netherlands

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MEDLINETA: Regul Pept

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