Synaptic Ca2+ in darkness is lower in rods than cones, causing slower tonic release of vesicles.

Synaptic Ca2+ in darkness is lower in rods than cones, causing slower tonic release of vesicles. Research Abstract Details 

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Synaptic Ca2+ in darkness is lower in rods than cones, causing slower tonic release of vesicles. Abstract Text:

Zejuan Sheng,Sue-Yeon Choi,Ajay Dharia,Jian Li,Peter Sterling,Richard H Kramer,

Rod and cone photoreceptors use specialized biochemistry to generate light responses that differ in their sensitivity and kinetics. However, it is unclear whether there are also synaptic differences that affect the transmission of visual information. Here, we report that in the dark, rods tonically release synaptic vesicles at a much slower rate than cones, as measured by the release of the fluorescent vesicle indicator FM1-43. To determine whether slower release results from a lower Ca2+ sensitivity or a lower dark concentration of Ca2+, we imaged fluorescent indicators of synaptic vesicle cycling and intraterminal Ca2+. We report that the Ca2+ sensitivity of release is indistinguishable in rods and cones, consistent with their possessing similar release machinery. However, the dark intraterminal Ca2+ concentration is lower in rods than in cones, as determined by two-photon Ca2+ imaging. The lower level of dark Ca2+ ensures that rods encode intensity with a slower vesicle release rate that is better matched to the lower information content of dim light.

Synaptic Ca2+ in darkness is lower in rods than cones, causing slower tonic release of vesicles. Publishing Authors By Initials

Z Sheng,SY Choi,A Dharia,J Li,P Sterling,RH Kramer,

For similar sensation: vision research abstracts see: sensation: vision research

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Synaptic Ca2+ in darkness is lower in rods than cones, causing slower tonic release of vesicles. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: The Journal of neuroscience : the official journal

VOLUME: 27

Page Numbers: 5033-42

Journal Abbreviation: J. Neurosci.

ISSN: 1529-2401

DAY: 9

MONTH: May

YEAR: 2007

Synaptic Ca2+ in darkness is lower in rods than cones, causing slower tonic release of vesicles. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8102140

Synaptic Ca2+ in darkness is lower in rods than cones, causing slower tonic release of vesicles. Keywords Mesh Terms:

KEYWORDS: Vision

MESH TERMS: physiology

Chemical & Substance for Abstract: Synaptic Ca2+ in darkness is lower in rods than cones, causing slower tonic release of vesicles. Information

Substance Name: Fura-2

Registry Number: 96314-98-6

Grant and Affiliation Information for Synaptic Ca2+ in darkness is lower in rods than cones, causing slower tonic release of vesicles.

AFFILIATION: Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA.

Country: United States

AGENCY: United States NEI

GRANT: EY15514

ACRONYM: EY

MEDLINETA: J Neurosci

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