Synapses between corticotropin-releasing factor-containing axon terminals and dopaminergic neurons in the ventral tegmental area are predominantly glutamatergic.

Synapses between corticotropin-releasing factor-containing axon terminals and dopaminergic neurons in the ventral tegmental area are predominantly glutamatergic. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Synapses between corticotropin-releasing factor-containing axon terminals and dopaminergic neurons in the ventral tegmental area are predominantly glutamatergic. Abstract Text:

Patricia Tagliaferro,Marisela Morales,Patricia Tagliaferro,Marisela Morales,Patricia Tagliaferro,Marisela Morales,

Interactions between stress and the mesocorticolimbic dopamine (DA) system have been suggested from behavioral and electrophysiological studies. Because corticotropin-releasing factor (CRF) plays a role in stress responses, we investigated possible interactions between neurons containing CRF and those producing DA in the ventral tegmental area (VTA). We first investigated the cellular distribution of CRF in the VTA by immunolabeling VTA sections with anti-CRF antibodies and analyzing these sections by electron microscopy. We found CRF immunoreactivity present mostly in axon terminals establishing either symmetric or asymmetric synapses with VTA dendrites. We established that nearly all CRF asymmetric synapses are glutamatergic, insofar as the CRF-immunolabeled axon terminals in these synapses coexpressed the vesicular glutamate transporter 2, and that the majority of CRF symmetric synapses are GABAergic, insofar as the CRF-immunolabeled axon terminals in these synapses coexpressed glutamic acid decarboxylase, findings that are of functional importance. We then looked for synaptic interactions between CRF- and DA-containing neurons, by using antibodies against CRF and tyrosine hydroxylase (TH; a marker for DA neurons). We found that most synapses between CRF-immunoreactive axon terminals and TH neurons are asymmetric (in the majority likely to be glutamatergic) and suggest that glutamatergic neurons containing CRF may be part of the neuronal circuitry that mediates stress responses involving the mesocorticolimbic DA system. The presence of CRF synapses in the VTA offers a mechanism for interactions between the stress-associated neuropeptide CRF and the mesocorticolimbic DA system. J. Comp. Neurol. 506:616-626, 2008. Published 2007 Wiley-Liss, Inc.

Synapses between corticotropin-releasing factor-containing axon terminals and dopaminergic neurons in the ventral tegmental area are predominantly glutamatergic. Publishing Authors By Initials

P Tagliaferro,M Morales,P Tagliaferro,M Morales,P Tagliaferro,M Morales,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Synapses between corticotropin-releasing factor-containing axon terminals and dopaminergic neurons in the ventral tegmental area are predominantly glutamatergic. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Journal of comparative neurology

VOLUME: 506

Page Numbers: 616-26

Journal Abbreviation: J. Comp. Neurol.

ISSN: 0021-9967

DAY: 1

MONTH: Feb

YEAR: 2008

Synapses between corticotropin-releasing factor-containing axon terminals and dopaminergic neurons in the ventral tegmental area are predominantly glutamatergic. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 406041

Synapses between corticotropin-releasing factor-containing axon terminals and dopaminergic neurons in the ventral tegmental area are predominantly glutamatergic. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Synapses between corticotropin-releasing factor-containing axon terminals and dopaminergic neurons in the ventral tegmental area are predominantly glutamatergic. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Synapses between corticotropin-releasing factor-containing axon terminals and dopaminergic neurons in the ventral tegmental area are predominantly glutamatergic.

AFFILIATION: Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Comp Neurol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Synapses between corticotropin-releasing factor-containing axon terminals and dopaminergic neurons in the ventral tegmental area are predominantly glutamatergic Related Publications

• An attempt to detect phosphorylated myosin by ADP-ATP exchange.
• C-type natriuretic peptide and its relation to non-invasive indices of left ventricular function in patients with chronic heart failure.
• Chondrocyte moves: clever strategies?
• DPP10 is an inactivation modulatory protein of Kv4.3 and Kv1.4.
• Defining the role of insulin detemir in Basal insulin therapy.
• Development of an ultra-performance liquid chromatography technique coupled with mass spectrometry for the measurement of tacrolimus in micro-samples of whole blood, and its application on a pharmacokiinetic trial.
• Does the use of recombinant AAV2 in pulmonary gene therapy damage lung function?
• Effect of in vitro enzymatic digestion on antioxidant activity of coffee melanoidins and fractions.
• Fluorescence staining of glycerinated myofibrils with 1-anilino naphthalene-8-sulfonate.
• Frequency and causes of infectious abortion in a dairy herd in Queretaro, Mexico.
• GABAergic processes in the mesencephalic tegmentum modulate the occurrence of active (rapid eye movement) sleep in guinea pigs.
• Influence of the new immunosuppressive combinations on arterial hypertension after renal transplantation.
• Iron-deficiency anemia as presentation of pouchitis.
• Language access services for Latinos with limited English proficiency: lessons learned from Hablamos Juntos.
• Life-history strategies of plant pathogens: distribution patterns and phylogenetic analysis.
• Nanopore current transduction analysis of protein binding to non-terminal and terminal DNA regions: analysis of transcription factor binding, retroviral DNA terminus dynamics, and retroviral integrase-DNA binding.
• Noncholinesterase effects induced by organophosphate pesticides and their relationship to cognitive processes: implication for the action of acylpeptide hydrolase.
• P31.15: First results of biochemical screening and combined ultrasound of fetal chromosomal disorders in the first trimester of pregnancy in Ecuador.
• Patterns of early adherence to the antidepressant citalopram among older primary care patients: the prospect study.
• Protective effect of vitamin C towards N-nitrosamine-induced DNA damage in the single-cell gel electrophoresis (SCGE)/HepG2 assay.
• Relations and effects of transformational leadership: a comparative analysis with traditional leadership styles.
• Relationship Between Body Mass Index and Measures of Sport Participation in Junior Female Volleyball Players: 2143: Board #56 June 1 9:00 AM - 10:30 AM.
• Renal damage associated with proteinuria.
• Responding to human trafficking in Connecticut: a guide for health-care providers.
• Structural control over well productivity in the Jundiaí River Catchment, Southeastern Brazil.
• Synapses between corticotropin-releasing factor-containing axon terminals and dopaminergic neurons in the ventral tegmental area are predominantly glutamatergic.
• Unmasking the Brugada syndrome with high parasternal leads.
• Words of wisdom. Re: detection of circulating urothelial cancer cells in the blood using the CellSearch system.
• Xenopus laevis: a possible vector of ranavirus infection?
• [Introduction: clinical relevance of graft-induced immunological injury after renal transplantation]