Symptoms of anxiety and depression in patients with stable coronary heart disease: prognostic value and consideration of pathogenetic links.

Symptoms of anxiety and depression in patients with stable coronary heart disease: prognostic value and consideration of pathogenetic links. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Symptoms of anxiety and depression in patients with stable coronary heart disease: prognostic value and consideration of pathogenetic links. Abstract Text:

Dietrich Rothenbacher,Harry Hahmann,Bernd ,Wolfgang Koenig,Hermann Brenner,

BACKGROUND: We evaluated the association of symptoms of anxiety and depression with fatal and non-fatal cardiovascular disease events among patients with coronary heart disease and considered several potential underlying pathogenetic links. DESIGN: This was a prospective cohort study. METHODS: In this study, including coronary heart disease patients undergoing an in-patient rehabilitation program, symptoms of anxiety and depression were evaluated with the Hospital Anxiety and Depression Scale (HADS). Fatal and non-fatal cardiovascular disease events were determined during a 3-year follow-up. RESULTS: Of the 1052 patients with CHD 16.1% showed a borderline and 8.3% a manifest anxiety symptoms score, whereas 11.8 and 5.9% showed a borderline and manifest depressive symptoms score, respectively. During the 3-year follow-up fatal and non-fatal cardiovascular disease events were observed in 73 (6.9%) patients. After adjustment for covariates, patients having manifest anxiety symptoms had a statistically significant hazard ratio (HR) of 2.32 [95% confidence interval (CI) 1.14-4.74] for a cardiovascular disease event, and patients with depressive symptoms had an HR of 1.47 (95% CI 0.62-3.51) compared to other patients. In a model considering anxiety and depressive symptom scores simultaneously, the hazard ratio for a cardiovascular disease event associated with anxiety symptoms increased to 3.31 (95% CI 1.32-8.27), whereas the hazard ratio associated with depressive symptoms decreased (HR 0.62; 95% CI 0.20-1.87). We found a positive association of increased anxiety scores with body mass index and systolic blood pressure. CONCLUSIONS: The study suggests an important role especially for symptoms of anxiety for long-term prognosis of patients with known coronary heart disease. It furthermore suggests that several pathogenetic links may partly explain the increased risk.

Symptoms of anxiety and depression in patients with stable coronary heart disease: prognostic value and consideration of pathogenetic links. Publishing Authors By Initials

D Rothenbacher,H Hahmann,B ,W Koenig,H Brenner,

For similar investigative techniques: epidemiologic methods: statistics as topic: probability: risk: risk factors research abstracts see: investigative techniques: epidemiologic methods: statistics as topic: probability: risk: risk factors research

PUBMED ID PMID:

MEDLINE DATE:

Symptoms of anxiety and depression in patients with stable coronary heart disease: prognostic value and consideration of pathogenetic links. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: European journal of cardiovascular prevention and

VOLUME: 14

Page Numbers: 547-54

Journal Abbreviation:

ISSN: 1741-8267

DAY: 20

MONTH: Aug

YEAR: 2007

Symptoms of anxiety and depression in patients with stable coronary heart disease: prognostic value and consideration of pathogenetic links. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101192000

Symptoms of anxiety and depression in patients with stable coronary heart disease: prognostic value and consideration of pathogenetic links. Keywords Mesh Terms:

KEYWORDS: Risk Factors

MESH TERMS: epidemiology

Chemical & Substance for Abstract: Symptoms of anxiety and depression in patients with stable coronary heart disease: prognostic value and consideration of pathogenetic links. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Symptoms of anxiety and depression in patients with stable coronary heart disease: prognostic value and consideration of pathogenetic links.

AFFILIATION: Division of Clinical Epidemiology and Aging Research, The German Cancer Research Center, Heidelberg, Germany. d.rothenbacher@dkfz-heidelberg.de

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Eur J Cardiovasc Prev Rehabil

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Symptoms of anxiety and depression in patients with stable coronary heart disease: prognostic value and consideration of pathogenetic links Related Publications

• Adolescents as victims of familial violence: a hospital based surveillance.
• An S6 mutation in BK channels reveals beta1 subunit effects on intrinsic and voltage-dependent gating.
• Antiprogestin-releasing intrauterine devices: a novel approach to endometrial contraception.
• BMP-2, BMP-4, and PDGF-bb stimulate chemotactic migration of primary human mesenchymal progenitor cells.
• Cadherin-11 in synovial lining formation and pathology in arthritis.
• Cost-saving analysis of screening colonoscopy in Germany.
• Differential role of I kappa B kinase 1 and 2 in primary rat hepatocytes.
• Effect of insulin on the oxidative desaturation ofa-linolenic, oleic and palmitic acids.
• Epidemiology of chronic atrophic gastritis: population-based study among 9444 older adults from Germany.
• Fifth Annual ISHAGE Meeting - Oslo 1999.
• Haptic search with finger movements: using more fingers does not necessarily reduce search times.
• Losartan in patients with type 2 diabetes and proteinuria: Observations from the RENAAL Study.
• Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+.
• Non-invasive in vivo diffuse optical spectroscopy monitoring of cyanide poisoning in a rabbit model.
• Phase I dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemopreventive agent.
• Protein molecular function prediction by Bayesian phylogenomics.
• Radiation-induced leukemia at doses relevant to radiation therapy: modeling mechanisms and estimating risks.
• Relation between neural response telemetry thresholds, T- and C-levels, and loudness judgments in 12 adult nucleus 24 cochlear implant recipients.
• Relative incorporation of linoleic and arachidonic acid in phospholipids and triglycerides of different rat tissues.
• Symptoms of anxiety and depression in patients with stable coronary heart disease: prognostic value and consideration of pathogenetic links.
• Systemic mediators induce fibrogenic effects in normal liver after partial bile duct ligation.
• Testing the stand-alone microbeam at Columbia University.
• The continuing contribution of gene marking to cell and gene therapy.
• The forkhead transcription factor FoxO1 regulates proliferation and transdifferentiation of hepatic stellate cells.
• The more eyes, the better to see? From double to quadruple reading of screening mammograms.
• The phosphatidyl ethanolamine ofPseudomonas aeruginosa grown in hexadecane.
• Timely disclosure of progress in childhood cancer survival by 'period' analysis in the Automated Childhood Cancer Information System.
• Trends in population-based cancer survival in Germany: to what extent does progress reach older patients?
• Update on the pfam5000 strategy for selection of structural genomics targets.
• Vascular endothelial growth factor stimulates chemotactic migration of primary human osteoblasts.