Symptomatic and asymptomatic viral recrudescence in solid-organ transplant recipients and its relationship with the antigen-specific CD8(+) T-cell response.

Symptomatic and asymptomatic viral recrudescence in solid-organ transplant recipients and its relationship with the antigen-specific CD8(+) T-cell response. Research Abstract Details 

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Symptomatic and asymptomatic viral recrudescence in solid-organ transplant recipients and its relationship with the antigen-specific CD8(+) T-cell response. Abstract Text:

Tania Crough,Chrysa Fazou,Julissa Weiss,Scott Campbell,Miles P Davenport,Scott C Bell,Andrew Galbraith,Keith McNeil,Rajiv Khanna,Tania Crough,Chrysa Fazou,Julissa Weiss,Scott Campbell,Miles P Davenport,Scott C Bell,Andrew Galbraith,Keith McNeil,Rajiv Khanna,

Using ex vivo antigen-specific T-cell analysis, we found that symptomatic cytomegalovirus recrudescence in transplant recipients was coincident with reduced expression of gamma interferon (IFN-gamma) by virus-specific CD8(+) T cells and an up-regulation of CD38 expression on these T cells, although there was no significant change in the absolute number of virus-specific cells (as assessed by major histocompatibility complex-peptide multimers). In contrast, HLA class I-matched transplant patients with asymptomatic viral recrudescence showed increased expansion of antigen-specific T cells and highly stable IFN-gamma expression by epitope-specific T cells. These studies suggest that a strong functional T-cell response plays a crucial role in defining the clinical outcome of acute viral recrudescence.

Symptomatic and asymptomatic viral recrudescence in solid-organ transplant recipients and its relationship with the antigen-specific CD8(+) T-cell response. Publishing Authors By Initials

T Crough,C Fazou,J Weiss,S Campbell,MP Davenport,SC Bell,A Galbraith,K McNeil,R Khanna,T Crough,C Fazou,J Weiss,S Campbell,MP Davenport,SC Bell,A Galbraith,K McNeil,R Khanna,

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Symptomatic and asymptomatic viral recrudescence in solid-organ transplant recipients and its relationship with the antigen-specific CD8(+) T-cell response. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of virology

VOLUME: 81

Page Numbers: 11538-42

Journal Abbreviation: J. Virol.

ISSN: 0022-538X

DAY: 8

MONTH: 08

YEAR: 2007

Symptomatic and asymptomatic viral recrudescence in solid-organ transplant recipients and its relationship with the antigen-specific CD8(+) T-cell response. Information

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LANGUAGE: eng

NlmUniqueID: 113724

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AFFILIATION: Australian Centre for Vaccine Development and Tumour Immunology Laboratory, Division of Infectious Diseases and Immunology, Queensland Institute of Medical Research, 300 Herston Road, Brisbane, Queensland 4029, Australia.

Country: United States

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MEDLINETA: J Virol

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