Switching on chromatin: mechanistic role of histone H4-K16 acetylation.

Switching on chromatin: mechanistic role of histone H4-K16 acetylation. Research Abstract Details 

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Switching on chromatin: mechanistic role of histone H4-K16 acetylation. Abstract Text:

Michael Shogren-Knaak,Craig L Peterson,

How post-translational histone modifications regulate DNA utilization constitutes one of the central questions of chromatin biology. In studying the mechanistic role of histone H4-K16 acetylation, a mark with a functional role in maintaining transcriptionally permissive DNA domains or directly promoting gene transcription, we found that this acetylation both disrupts higher-order chromatin structure and changes the functional interaction of chromatin-associated proteins. The potential significance of this finding for in vivo chromatin structure, establishment of euchromatic domains, and promotion of gene transcription is examined.

Switching on chromatin: mechanistic role of histone H4-K16 acetylation. Publishing Authors By Initials

M Shogren-Knaak,CL Peterson,

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Switching on chromatin: mechanistic role of histone H4-K16 acetylation. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Cell cycle (Georgetown, Tex.)

VOLUME: 5

Page Numbers: 1361-5

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ISSN: 1551-4005

DAY: 1

MONTH: 07

YEAR: 2006

Switching on chromatin: mechanistic role of histone H4-K16 acetylation. Information

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LANGUAGE: eng

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AFFILIATION: Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA. knaak@iastate.edu

Country: United States

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MEDLINETA: Cell Cycle

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