Sweet delivery - sugar translocators as ports of entry for antisense oligodeoxynucleotides in plant cells.

Sweet delivery - sugar translocators as ports of entry for antisense oligodeoxynucleotides in plant cells. Research Abstract Details 

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Sweet delivery - sugar translocators as ports of entry for antisense oligodeoxynucleotides in plant cells. Abstract Text:

Chuanxin Sun,Karin ,Anna-Stina ,Lars-Gunnar Larsson,Christer Jansson,Chuanxin Sun,Karin Ridderstråle,Anna-Stina Höglund,Lars-Gunnar Larsson,Christer Jansson,

Antisense oligodeoxynucleotides (ODNs) are short (12-25 nt long) stretches of single-stranded DNA that may be delivered to a cell, where they hybridize to the cognate mRNA in a sequence-specific manner, thereby inhibiting gene expression. Here we used confocal microscopy to monitor the uptake and trafficking of ODNs in barley tissues. We conclude that uptake of ODNs across the plant plasma membrane is mediated by active transport of mono- or disaccharides through sugar translocators. We demonstrate that sugar transport can deliver ODNs to barley seeds, and that this strategy may be employed to suppress gene activity in endosperm cells by antisense ODN inhibition. We further found that sucrose compared favorably with oligofectamine as a vehicle for ODN delivery to human cells in a low-serum environment.

Sweet delivery - sugar translocators as ports of entry for antisense oligodeoxynucleotides in plant cells. Publishing Authors By Initials

C Sun,K ,AS ,LG Larsson,C Jansson,C Sun,K Ridderstråle,AS Höglund,LG Larsson,C Jansson,

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Sweet delivery - sugar translocators as ports of entry for antisense oligodeoxynucleotides in plant cells. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Plant journal : for cell and molecular biology

VOLUME: 52

Page Numbers: 1192-8

Journal Abbreviation: Plant J.

ISSN: 0960-7412

DAY: 6

MONTH: 10

YEAR: 2007

Sweet delivery - sugar translocators as ports of entry for antisense oligodeoxynucleotides in plant cells. Information

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LANGUAGE: eng

NlmUniqueID: 9207397

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Grant and Affiliation Information for Sweet delivery - sugar translocators as ports of entry for antisense oligodeoxynucleotides in plant cells.

AFFILIATION: Department of Plant Biology & Forest Genetics, The Swedish University of Agricultural Sciences (SLU), Uppsala BioCenter, PO Box 7080, SE-75007 Uppsala, Sweden.

Country: England

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MEDLINETA: Plant J

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