Sustained-release naltrexone: novel treatment for opioid dependence.

Sustained-release naltrexone: novel treatment for opioid dependence. Research Abstract Details 

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Sustained-release naltrexone: novel treatment for opioid dependence. Abstract Text:

Sandra D Comer,Maria A Sullivan,Gary K Hulse,

The devastating costs of opioid abuse and dependence underscore the need for effective treatments for these disorders. At present, several different maintenance medications exist for treating opioid dependence, including methadone, buprenorphine and naltrexone. Of these, naltrexone is the only one that possesses no opioid agonist effects. Instead, naltrexone occupies opioid receptors and prevents or reverses the effects produced by opioid agonists. Despite its clear pharmacologic effectiveness, its clinical effectiveness in treating opioid dependence has been disappointing, primarily due to non-compliance with taking the medication. However, the recent availability of sustained-release formulations of naltrexone has renewed interest in this medication. The present paper describes the development of sustained-release naltrexone formulations and discusses the clinical issues associated with their use in treating opioid dependence.

Sustained-release naltrexone: novel treatment for opioid dependence. Publishing Authors By Initials

SD Comer,MA Sullivan,GK Hulse,

For similar disorders of environmental origin: substance-related disorders: opioid-related disorders research abstracts see: disorders of environmental origin: substance-related disorders: opioid-related disorders research

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Sustained-release naltrexone: novel treatment for opioid dependence. Journal Published:

PUBLICATION TYPE: Review

Journal: Expert opinion on investigational drugs

VOLUME: 16

Page Numbers: 1285-94

Journal Abbreviation:

ISSN: 1744-7658

DAY: 3

MONTH: Aug

YEAR: 2007

Sustained-release naltrexone: novel treatment for opioid dependence. Information

Number of References: 105

LANGUAGE: eng

NlmUniqueID: 9434197

Sustained-release naltrexone: novel treatment for opioid dependence. Keywords Mesh Terms:

KEYWORDS: Opioid-Related Disorders

MESH TERMS: metabolism

Chemical & Substance for Abstract: Sustained-release naltrexone: novel treatment for opioid dependence. Information

Substance Name: Naltrexone

Registry Number: 16590-41-3

Grant and Affiliation Information for Sustained-release naltrexone: novel treatment for opioid dependence.

AFFILIATION: College of Physicians & Surgeons of Columbia University, New York State Psychiatric Institute, Department of Psychiatry, Unit 120, New York, NY 10032, USA. sdc10@columbia.edu

Country: England

AGENCY: United States NIDA

GRANT: DA09236

ACRONYM: DA

MEDLINETA: Expert Opin Investig Drugs

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