Sustained neocortical neurogenesis after neonatal hypoxic/ischemic injury.

Sustained neocortical neurogenesis after neonatal hypoxic/ischemic injury. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Sustained neocortical neurogenesis after neonatal hypoxic/ischemic injury. Abstract Text:

OBJECTIVE: Neocortical neurons are sensitive to hypoxic-ischemic (H-I) injuries at term and their demise contributes to neurological disorders. Here we tested the hypothesis that the subventricular zone of the immature brain regenerates neocortical neurons, and that this response is sustained. METHODS: Systemic injections of 5-bromo-2'-deoxyuridine (BrdU) and intraventricular injections of replication-deficient retroviruses were used to label newly born cells, and confocal microscopy after immunofluorescence was used to phenotype the new cells from several days to several months after perinatal H-I in the postnatal day 6 rat. Quantitative polymerase chain reaction was used to evaluate chemoattractants, growth factors, and receptors. RESULTS: Robust production of new neocortical neurons after perinatal H-I occurs. These new neurons are descendants of the subventricular zone, and they colonize the cell-sparse columns produced by the injury to the neocortex. These columns are populated by reactive astrocytes and microglia. Surprisingly, this neuronogenesis is sustained for months. Molecular analyses demonstrated increased neocortical production of insulin-like growth factor-1 and monocyte chemoattractant factor-1 (but statistically insignificant production of erythropoietin, brain-derived neurotrophic factor, glial-derived neurotrophic factor, and transforming growth factor-alpha). INTERPRETATION: The young nervous system has long been known to possess a greater capacity to recover from injury than the adult system. Our data indicate that H-I injury in the neonatal brain initiates an enduring regenerative response from the subventricular zone. These data suggest that additional mechanisms than those previously surmised contribute to the remarkable ability of the immature brain to recover from injury.

Sustained neocortical neurogenesis after neonatal hypoxic/ischemic injury. Publishing Authors By Initials

For similar cells: stem cells research abstracts see: cells: stem cells research

PUBMED ID PMID:

MEDLINE DATE:

Sustained neocortical neurogenesis after neonatal hypoxic/ischemic injury. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Annals of neurology

VOLUME: 61

Page Numbers: 199-208

Journal Abbreviation: Ann. Neurol.

ISSN: 0364-5134

DAY: 3

MONTH: Mar

YEAR: 2007

Sustained neocortical neurogenesis after neonatal hypoxic/ischemic injury. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7707449

Sustained neocortical neurogenesis after neonatal hypoxic/ischemic injury. Keywords Mesh Terms:

KEYWORDS: Stem Cells

MESH TERMS: metabolism

Chemical & Substance for Abstract: Sustained neocortical neurogenesis after neonatal hypoxic/ischemic injury. Information

Substance Name: Receptors, Chemokine

Registry Number: 0

Grant and Affiliation Information for Sustained neocortical neurogenesis after neonatal hypoxic/ischemic injury.

AFFILIATION: Department of Neurology and Neurosciences, UMDNJ-New Jersey Medical School, New Jersey Institute of Technology, Newark, NJ 07103, USA.

Country: United States

AGENCY: United States NIMH

GRANT: MH 59950

ACRONYM: MH

MEDLINETA: Ann Neurol

REFSOURCE: Ann Neurol. 2007 Mar;61(3):185-6

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Sustained neocortical neurogenesis after neonatal hypoxic/ischemic injury Related Publications

• 17beta-Estradiol protects the neonatal brain from hypoxia-ischemia.
• A Case of Hydro-Nephrosis of Movable Kidney.
• A Plea for the Immediate Operation of Fractures.
• An audit of the use of agreed treatment protocols at a major centre for cancer treatment.
• Asymptomatic bacteriuria in the elderly.
• Ciliary neurotrophic factor and interleukin-6 differentially activate microglia.
• Death effector activation in the subventricular zone subsequent to perinatal hypoxia/ischemia.
• Hernia of the Bladder.
• Intestinal Obstruction.
• Killian and Guisez Clinics.
• Leukemia inhibitory factor participates in the expansion of neural stem/progenitors after perinatal hypoxia/ischemia.
• MOUNT ZION HOSPITAL NOTES SAN FRANCISCO.
• Operative Treatment for Tic Douloureaux of the Inferior Dental Nerve.
• Perinatal hypoxic/ischemic brain injury induces persistent production of striatal neurons from subventricular zone progenitors.
• Post Operative Acidosis.
• Post-Operative Phlebitis.
• REPORT OF A CASE OF STENOSIS OF THE DUODENUM DUE TO GALL STONES; OPERATION; RECOVERY.
• Radiation cancer of the pharynx.
• Recollections of the Listerian Epoch.
• Remarks on the Sturge-Kalischer-Weber-Dimitri-Krabbe disease.
• Respiratory obstruction in acute leukaemia.
• Spontaneous regression of a malignant melanoma.
• Sustained neocortical neurogenesis after neonatal hypoxic/ischemic injury.
• The Relation of Gastric Hemorrhage to Chronic Appendicitis.
• The assessment of proliferating cell nuclear antigen (PCNA) immunostaining in primary gastrointestinal lymphomas and its relationship to histological grade, S + G2 + M phase fraction (flow cytometric analysis) and prognosis. A. L. Woods, P. A. Hall, N. A.
• The economics of vein disease.
• The effect of lysozyme on canine gastrointestinal mucosa; further study.
• The ostrich syndrome: obstetrician gynecologists and human immunodeficiency virus exposure.
• Treatment of the Spiral Fractures of the Tibia.
• [Evaluation of disability in nervous diseases by the disability insurance court.]