Susceptibility to sequelae of human ocular chlamydial infection associated with allelic variation in IL10 cis-regulation.

Susceptibility to sequelae of human ocular chlamydial infection associated with allelic variation in IL10 cis-regulation. Research Abstract Details 

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Susceptibility to sequelae of human ocular chlamydial infection associated with allelic variation in IL10 cis-regulation. Abstract Text:

Angels Natividad,Martin J Holland,Kirk A Rockett,Julian Forton,Nkoyo Faal,Hassan M Joof,David C W Mabey,Robin L Bailey,Dominic P Kwiatkowski,Angels Natividad,Martin J Holland,Kirk A Rockett,Julian Forton,Nkoyo Faal,Hassan M Joof,David C W Mabey,Robin L Bailey,Dominic P Kwiatkowski,

Trachoma, an infectious disease of the conjunctiva caused by Chlamydia trachomatis, causes scarring and blindness in some infected individuals but not others. In an African community where trachoma is endemic, we have previously identified an IL10 haplotype that is associated with increased risk of scarring complications. Here we examine the hypothesis that the risk haplotype (H-RISK) affects levels of IL10 expression in the conjunctiva during active trachoma infection. To overcome potential genetic and environmental confounders we used the method of allele-specific quantification, which involved identifying subjects in the community who had active trachoma and were also heterozygous for the H-RISK. We find that there is allelic variation in cis-regulation of IL10 in the conjunctiva during active trachoma, with the H-RISK generating relatively more IL10 transcripts than other haplotypes in this population (average difference in IL10 allelic transcripts in the conjunctiva of heterozygous individuals infected with C. trachomatis of 23% (95% confidence interval: 14-32%, P < 0.0001). These findings provide a plausible functional explanation for the observed genetic association, and support the hypothesis that an excessive IL10 response to C. trachomatis infection is a risk factor for scarring and blindness.

Susceptibility to sequelae of human ocular chlamydial infection associated with allelic variation in IL10 cis-regulation. Publishing Authors By Initials

A Natividad,MJ Holland,KA Rockett,J Forton,N Faal,HM Joof,DC Mabey,RL Bailey,DP Kwiatkowski,A Natividad,MJ Holland,KA Rockett,J Forton,N Faal,HM Joof,DC Mabey,RL Bailey,DP Kwiatkowski,

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Susceptibility to sequelae of human ocular chlamydial infection associated with allelic variation in IL10 cis-regulation. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Human molecular genetics

VOLUME: 17

Page Numbers: 323-9

Journal Abbreviation: Hum. Mol. Genet.

ISSN: 0964-6906

DAY: 18

MONTH: 10

YEAR: 2007

Susceptibility to sequelae of human ocular chlamydial infection associated with allelic variation in IL10 cis-regulation. Information

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LANGUAGE: eng

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