Susceptibility patterns of Escherichia coli: prevalence of multidrug-resistant isolates and extended spectrum beta-lactamase phenotype.

Susceptibility patterns of Escherichia coli: prevalence of multidrug-resistant isolates and extended spectrum beta-lactamase phenotype. Research Abstract Details 

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Susceptibility patterns of Escherichia coli: prevalence of multidrug-resistant isolates and extended spectrum beta-lactamase phenotype. Abstract Text:

M Iqbal,I K Patel,S H Shah,Q Ain,N Barney,Q Kiani,K Z Rabbani,G Zaidi,B Mehdi,

OBJECTIVE: To study Escherichia coli (E. coli) susceptibility, prevalence of multidrug-resistant isolates and possible role of extended spectrum beta-lactamases (ESBL) in E. coli resistance. SETTING: Department of Medicine, Shifa College of Medicine, Islamabad. METHODS: Three hundred and seventy eight E. coli isolates from different sources were identified during six-month period. Susceptibility to various antibiotics was checked using standard methods. Multidrug-resistant isolates were separated. Isolates resistant to cefpodoxime and aztreonam were considered as ESBL phenotype, indicating ESBL production. RESULTS: Most of isolates were resistant to ampicillin and trimethoprim/sulfamethoxazole. Overall resistance to ciprofloxacin, ceftriaxone, cefotaxime and cefpodoxime was 49%, 34%, 36% and 38% respectively. Resistance to fourth generation cephalosporins was lower. Almost all Isolates were sensitive to amikacin, imipenem and tazobactam. Aztreonam resistance was found in 25% isolates. Similar pattern was observed for urinary E. coli isolates; 45% E. coli isolates were found to be multidrug-resistant. Nitrofurantoin showed low-level resistance both to multidrug-resistant as well as urinary isolates. Resistance to both cefpodoxime and aztreonam was found in 25% isolates suggesting ESBL production. CONCLUSION: E. coli resistance in Pakistan is much higher than reported from western literature. Multidrug-resistant isolates, including third generation cephalosporins and quinolones, are very common. ESBL production may contribute to this high level resistance against beta-lactams.

Susceptibility patterns of Escherichia coli: prevalence of multidrug-resistant isolates and extended spectrum beta-lactamase phenotype. Publishing Authors By Initials

M Iqbal,IK Patel,SH Shah,Q Ain,N Barney,Q Kiani,KZ Rabbani,G Zaidi,B Mehdi,

For similar biological phenomena, cell phenomena, and immunity: biological phenomena: microbiologic phenomena: drug resistance, microbial: drug resistance, bacterial: beta-lactam resistance research abstracts see: biological phenomena, cell phenomena, and immunity: biological phenomena: microbiologic phenomena: drug resistance, microbial: drug resistance, bacterial: beta-lactam resistance research

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Susceptibility patterns of Escherichia coli: prevalence of multidrug-resistant isolates and extended spectrum beta-lactamase phenotype. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: JPMA. The Journal of the Pakistan Medical Associat

VOLUME: 52

Page Numbers: 407-11

Journal Abbreviation:

ISSN: 0030-9982

DAY: 12

MONTH: Sep

YEAR: 2002

Susceptibility patterns of Escherichia coli: prevalence of multidrug-resistant isolates and extended spectrum beta-lactamase phenotype. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7501162

Susceptibility patterns of Escherichia coli: prevalence of multidrug-resistant isolates and extended spectrum beta-lactamase phenotype. Keywords Mesh Terms:

KEYWORDS: beta-Lactam Resistance

MESH TERMS: genetics

Chemical & Substance for Abstract: Susceptibility patterns of Escherichia coli: prevalence of multidrug-resistant isolates and extended spectrum beta-lactamase phenotype. Information

Substance Name: Ciprofloxacin

Registry Number: 85721-33-1

Grant and Affiliation Information for Susceptibility patterns of Escherichia coli: prevalence of multidrug-resistant isolates and extended spectrum beta-lactamase phenotype.

AFFILIATION: Department of Medicine, Shifa College of Medicine and International Hospital, Islamabad.

Country: Pakistan

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MEDLINETA: J Pak Med Assoc

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