Survivin repression by p53, Rb and E2F2 in normal human melanocytes.

Survivin repression by p53, Rb and E2F2 in normal human melanocytes. Research Abstract Details 

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Survivin repression by p53, Rb and E2F2 in normal human melanocytes. Abstract Text:

Deepak Raj,Tong Liu,George Samadashwily,Fengzhi Li,Douglas Grossman,Deepak Raj,Tong Liu,George Samadashwily,Fengzhi Li,Douglas Grossman,

The inhibitor of apoptosis protein survivin is a dual mediator of apoptosis resistance and cell cycle progression and is highly expressed in cancer. We have shown previously that survivin is up-regulated in melanoma compared with normal melanocytes, is required for melanoma cell viability, and that melanocyte expression of survivin predisposes mice to ultraviolet-induced melanoma and metastasis. The mechanism of survivin up-regulation in the course of melanocyte transformation and its repression in normal melanocytes, however, has not been clearly defined. We show here that p53 and retinoblastoma (Rb), at basal levels and in the absence of any activating stimuli, are both required to repress survivin transcription in normal human melanocytes. Survivin repression in melanocytes does not involve alterations in protein stability or promoter methylation. p53 and Rb (via E2Fs) regulate survivin expression by direct binding to the survivin promoter; p53 also affects survivin expression by activating p21. We demonstrate a novel role for E2F2 in the negative regulation of survivin expression. In addition, we identify a novel E2F-binding site in the survivin promoter and show that mutation of either the p53- or E2F-binding sites is sufficient to increase promoter activity. These studies suggest that compromise of either p53 or Rb pathways during melanocyte transformation leads to up-regulation of survivin expression in melanoma.

Survivin repression by p53, Rb and E2F2 in normal human melanocytes. Publishing Authors By Initials

D Raj,T Liu,G Samadashwily,F Li,D Grossman,D Raj,T Liu,G Samadashwily,F Li,D Grossman,

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Survivin repression by p53, Rb and E2F2 in normal human melanocytes. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Carcinogenesis

VOLUME: 29

Page Numbers: 194-201

Journal Abbreviation: Carcinogenesis

ISSN: 1460-2180

DAY: 4

MONTH: 10

YEAR: 2007

Survivin repression by p53, Rb and E2F2 in normal human melanocytes. Information

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LANGUAGE: eng

NlmUniqueID: 8008055

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Grant and Affiliation Information for Survivin repression by p53, Rb and E2F2 in normal human melanocytes.

AFFILIATION: Department of Dermatology, University of Utah, 30 North 1900 East, Salt Lake City, UT 84132, USA.

Country: England

AGENCY: United States NIAMS

GRANT: AR050102

ACRONYM: AR

MEDLINETA: Carcinogenesis

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