Survivin, cancer networks and pathway-directed drug discovery.

Survivin, cancer networks and pathway-directed drug discovery. Research Abstract Details 

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Survivin, cancer networks and pathway-directed drug discovery. Abstract Text:

Dario C Altieri,Dario C Altieri,Dario C Altieri,

Although there is no shortage of potential targets for cancer therapeutics, we know of only a handful of molecules that are differentially expressed in cancer and intersect multiple pathways required for tumour maintenance. Survivin embodies these properties, and orchestrates integrated cellular networks that are essential for tumour cell proliferation and viability. Pursuing the nodal functions of survivin in cancer might lead to the development of global pathway inhibitors with unique therapeutic potential.

Survivin, cancer networks and pathway-directed drug discovery. Publishing Authors By Initials

DC Altieri,DC Altieri,DC Altieri,

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Survivin, cancer networks and pathway-directed drug discovery. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Nature reviews. Cancer

VOLUME: 8

Page Numbers: 61-70

Journal Abbreviation: Nat. Rev. Cancer

ISSN: 1474-1768

DAY: 21

MONTH: Jan

YEAR: 2008

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LANGUAGE: eng

NlmUniqueID: 101124168

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Grant and Affiliation Information for Survivin, cancer networks and pathway-directed drug discovery.

AFFILIATION: Department of Cancer Biology and the Cancer Center, Lazare Research Building 428, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, USA. dario.altieri@umassmed.edu

Country: England

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MEDLINETA: Nat Rev Cancer

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