Survival efficacy of adjuvant cytosine-analogue CS-682 in a fluorescent orthotopic model of human pancreatic cancer.

Survival efficacy of adjuvant cytosine-analogue CS-682 in a fluorescent orthotopic model of human pancreatic cancer. Research Abstract Details 

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Survival efficacy of adjuvant cytosine-analogue CS-682 in a fluorescent orthotopic model of human pancreatic cancer. Abstract Text:

Matthew H Katz,Michael Bouvet,Shinako Takimoto,Daniel Spivack,Abdool R Moossa,Robert M Hoffman,

Adjuvant treatment with the cytosine analogue 1-(2-C-cyano-2-deoxy-beta-D-arabino-pentofuranosyl)-N(4)-palmitoylcytosine (CS-682) results in a highly significant increase in survival in the aggressive orthotopic MIA-PaCa-2 human pancreatic cancer mouse model. Seven days after implantation, mice were randomized into eight groups, depending on whether they were to be treated by tumor resection, 5 weeks of CS-682 chemotherapy at 40-60 mg/kg once daily, or both. Throughout the course of treatment, noninvasive optical whole-body imaging based on brilliant red fluorescent protein expression of the tumor permitted visualization and quantification of primary, metastatic, and recurrent disease. Total tumor burden negatively correlated with survival. Untreated mice died of disseminated disease with a median survival of 26 days. Surgical resection alone conferred a small but significant survival advantage (median survival, 28 days, P = 0.03). Primary CS-682 treatment at all doses also significantly prolonged survival compared with untreated animals (P < 0.05) and was more effective than surgery alone at doses of 50 and 60 mg/kg (median survival, 34 days, P = 0.045, and 38.5 days, P = 0.03, respectively). Maximal survival (median, 48 days, with 30% of animals surviving longer than 60 days) was achieved by adjuvant CS-682 (50 mg/kg), given after surgical resection of the primary pancreatic tumor (P = 0.004 compared with surgery alone). The results demonstrate that adjuvant oral administration of CS-682 for pancreatic cancer is highly effective with acceptable toxicity, suggesting its potential for cure of this disease in appropriate combinations.

Survival efficacy of adjuvant cytosine-analogue CS-682 in a fluorescent orthotopic model of human pancreatic cancer. Publishing Authors By Initials

MH Katz,M Bouvet,S Takimoto,D Spivack,AR Moossa,RM Hoffman,

For similar neoplasms: neoplasms by site: digestive system neoplasms: pancreatic neoplasms research abstracts see: neoplasms: neoplasms by site: digestive system neoplasms: pancreatic neoplasms research

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Survival efficacy of adjuvant cytosine-analogue CS-682 in a fluorescent orthotopic model of human pancreatic cancer. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Cancer research

VOLUME: 64

Page Numbers: 1828-33

Journal Abbreviation: Cancer Res.

ISSN: 0008-5472

DAY: 1

MONTH: Mar

YEAR: 2004

Survival efficacy of adjuvant cytosine-analogue CS-682 in a fluorescent orthotopic model of human pancreatic cancer. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2984705

Survival efficacy of adjuvant cytosine-analogue CS-682 in a fluorescent orthotopic model of human pancreatic cancer. Keywords Mesh Terms:

KEYWORDS: Pancreatic Neoplasms

MESH TERMS: pathology

Chemical & Substance for Abstract: Survival efficacy of adjuvant cytosine-analogue CS-682 in a fluorescent orthotopic model of human pancreatic cancer. Information

Substance Name: Cytosine

Registry Number: 71-30-7

Grant and Affiliation Information for Survival efficacy of adjuvant cytosine-analogue CS-682 in a fluorescent orthotopic model of human pancreatic cancer.

AFFILIATION: Department of Surgery, University of California at San Diego, San Diego, California, USA.

Country: United States

AGENCY: United States NCI

GRANT: R43 CA89779-01

ACRONYM: CA

MEDLINETA: Cancer Res

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