Surgical resection after gefitinib treatment in patients with lung adenocarcinoma harboring epidermal growth factor receptor gene mutation.

Surgical resection after gefitinib treatment in patients with lung adenocarcinoma harboring epidermal growth factor receptor gene mutation. Research Abstract Details 

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Surgical resection after gefitinib treatment in patients with lung adenocarcinoma harboring epidermal growth factor receptor gene mutation. Abstract Text:

Kazuya Takamochi,Kazuya Suzuki,Haruhiko Sugimura,Kazuhito Funai,Hiroki Mori,Abul Hasan Muhammad Bashar,Teruhisa Kazui,

Gefitinib is the first approved epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) for the treatment of patients with advanced non-small cell lung cancer (NSCLC) who failed to respond to conventional chemotherapy. Gefitinib has fairly effective anti-tumour activity in patients with tumours harboring EGFR gene mutations. However, there has been no data about the preoperative gefitinib treatment in NSCLC patients. We reported here two cases of surgical resection of residual disease after dramatic response to gefitinib in patients with lung adenocarcinoma harboring EGFR gene mutation. Because both of our patients initially had advanced local tumour burden (bulky N2 disease), complete resection would not have been technically feasible. However, preoperative gefitinib treatment made it possible to achieve complete resection in both patients. We believe that clinical trials are required to evaluate the role of preoperative treatment of EGFR-TKIs in patients with locally advanced NSCLC harboring EGFR gene mutation.

Surgical resection after gefitinib treatment in patients with lung adenocarcinoma harboring epidermal growth factor receptor gene mutation. Publishing Authors By Initials

K Takamochi,K Suzuki,H Sugimura,K Funai,H Mori,AH Bashar,T Kazui,

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Surgical resection after gefitinib treatment in patients with lung adenocarcinoma harboring epidermal growth factor receptor gene mutation. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Lung cancer (Amsterdam, Netherlands)

VOLUME: 58

Page Numbers: 149-55

Journal Abbreviation: Lung Cancer

ISSN: 0169-5002

DAY: 4

MONTH: 06

YEAR: 2007

Surgical resection after gefitinib treatment in patients with lung adenocarcinoma harboring epidermal growth factor receptor gene mutation. Information

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LANGUAGE: eng

NlmUniqueID: 8800805

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Grant and Affiliation Information for Surgical resection after gefitinib treatment in patients with lung adenocarcinoma harboring epidermal growth factor receptor gene mutation.

AFFILIATION: First Department of Surgery, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu 435-3192, Japan.

Country: Ireland

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MEDLINETA: Lung Cancer

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