Surgery and chemotherapy for small cell lung cancer in stages I-II with or without radiotherapy.

Surgery and chemotherapy for small cell lung cancer in stages I-II with or without radiotherapy. Research Abstract Details 

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Surgery and chemotherapy for small cell lung cancer in stages I-II with or without radiotherapy. Abstract Text:

Marc Bischof, Debus,Klaus Herfarth,Thomas Muley,Jutta Kappes,Konstantina Storz,Hans Hoffmann,

PURPOSE: To analyze the effectiveness of surgery and chemotherapy with or without radiotherapy in the management of limited small cell lung cancer (LSCLC) in stages I and II. PATIENTS AND METHODS: 39 patients (median age 62 years) with LSCLC in stages pT1 or pT2 and pN0 or pN1 (stages IA-IIB) who had a tumor resection and systematic lymph node dissection were reviewed retrospectively. The median follow-up period was 29 months. 35 patients (90%) received a median of four cycles of a platinum-containing chemotherapy postoperatively. 16 patients (41%) received an adjuvant thoracic radiotherapy (TRT, median 50 Gy); 21 patients (54%) received a prophylactic cranial irradiation (PCI, median 30 Gy). RESULTS: The median overall survival for all patients was 47 months, resulting in actuarial 1-, 3-, and 5-year survival rates of 97%, 58%, and 49%, respectively. Distant metastases were found in 13 patients (33%) after a median of 16 months. Patients who received an adjuvant TRT showed a trend toward improved thoracic recurrence-free survival (p = 0.06) and improved overall survival (p = 0.07) compared to those treated with surgery and chemotherapy only. Brain metastasis-free survival (p = 0.01) and overall survival (p = 0.01) were improved significantly in patients who received a PCI. CONCLUSION: Surgical tumor resection may be considered for carefully selected patients. Adjuvant chemotherapy and PCI are recommended for all patients. Adjuvant TRT is currently used in patients with positive lymph nodes (pN1), because the probability of a subclinical involvement of the mediastinal lymphatic system appears to be increased in these patients.

Surgery and chemotherapy for small cell lung cancer in stages I-II with or without radiotherapy. Publishing Authors By Initials

M Bischof,J Debus,K Herfarth,T Muley,J Kappes,K Storz,H Hoffmann,

For similar investigative techniques: epidemiologic methods: statistics as topic: survival analysis research abstracts see: investigative techniques: epidemiologic methods: statistics as topic: survival analysis research

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Surgery and chemotherapy for small cell lung cancer in stages I-II with or without radiotherapy. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Strahlentherapie und Onkologie : Organ der Deutsch

VOLUME: 183

Page Numbers: 679-84

Journal Abbreviation:

ISSN: 0179-7158

DAY: 11

MONTH: Dec

YEAR: 2007

Surgery and chemotherapy for small cell lung cancer in stages I-II with or without radiotherapy. Information

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LANGUAGE: eng

NlmUniqueID: 8603469

Surgery and chemotherapy for small cell lung cancer in stages I-II with or without radiotherapy. Keywords Mesh Terms:

KEYWORDS: Survival Analysis

MESH TERMS: administration & dosage

Chemical & Substance for Abstract: Surgery and chemotherapy for small cell lung cancer in stages I-II with or without radiotherapy. Information

Substance Name: Organoplatinum Compounds

Registry Number: 0

Grant and Affiliation Information for Surgery and chemotherapy for small cell lung cancer in stages I-II with or without radiotherapy.

AFFILIATION: Department of Radiooncology, University of Heidelberg, Germany. marc_bischof@med.uni-heidelberg.de

Country: Germany

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MEDLINETA: Strahlenther Onkol

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