Surface-modulated skin layers of thermal responsive hydrogels as on-off switches: II. Drug permeation.

Surface-modulated skin layers of thermal responsive hydrogels as on-off switches: II. Drug permeation. Research Abstract Details 

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Surface-modulated skin layers of thermal responsive hydrogels as on-off switches: II. Drug permeation. Abstract Text:

R Yoshida,K Sakai,T Okano,Y Sakurai,

'On-off' regulation of drug permeation through membranes in response to external temperature change has already been achieved using thermosensitive copolymers of N-isopropyl acrylamide (IPAAm) with butyl methacrylate (BMA). Increasing temperature induced formation of a dehydrated polymeric surface skin layer that stopped drug permeation. In this study, to control 'on-off' permeability of a drug, the polymer surface shrinking process was regulated by changing the length of alkyl side chain of the copolymer methacrylate component. Permeation experiments with indomethacin were performed in response to stepwise temperature changes between 20 and 30 degrees C with copolymers of IPAAm with BMA, hexyl methacrylate (HMA), and lauryl methacrylate (LMA). Burst permeation was found at the initial stage of the second 'on' period for both poly(IPAAm-co-HMA) and poly(IPAAm-co-LMA). These results suggest that drug diffuses during 'off' periods to change the concentration profile in the polymer gel. Polymer surface skin formation maintains a localized high water content inside the polymer gel even if drug permeation stops. The length of the alkyl side chain is an important parameter to control 'on-off' permeability of drug.

Surface-modulated skin layers of thermal responsive hydrogels as on-off switches: II. Drug permeation. Publishing Authors By Initials

R Yoshida,K Sakai,T Okano,Y Sakurai,

For similar environment and public health: environment: environment, controlled: temperature research abstracts see: environment and public health: environment: environment, controlled: temperature research

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Surface-modulated skin layers of thermal responsive hydrogels as on-off switches: II. Drug permeation. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of biomaterials science. Polymer edition

VOLUME: 3

Page Numbers: 243-52

Journal Abbreviation:

ISSN: 0920-5063

DAY: 20

MONTH: 02

YEAR: 1992

Surface-modulated skin layers of thermal responsive hydrogels as on-off switches: II. Drug permeation. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9007393

Surface-modulated skin layers of thermal responsive hydrogels as on-off switches: II. Drug permeation. Keywords Mesh Terms:

KEYWORDS: Temperature

MESH TERMS: chemistry

Chemical & Substance for Abstract: Surface-modulated skin layers of thermal responsive hydrogels as on-off switches: II. Drug permeation. Information

Substance Name: poly-N-isopropylacrylamide

Registry Number: 25189-55-3

Grant and Affiliation Information for Surface-modulated skin layers of thermal responsive hydrogels as on-off switches: II. Drug permeation.

AFFILIATION: Department of Chemical Engineering, Waseda University, Tokyo, Japan.

Country: NETHERLANDS

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MEDLINETA: J Biomater Sci Polym Ed

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