SuPr-1-mediated desumoylation regulates the repressor activity of DeltaNp63alpha.

SuPr-1-mediated desumoylation regulates the repressor activity of DeltaNp63alpha. Research Abstract Details 

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SuPr-1-mediated desumoylation regulates the repressor activity of DeltaNp63alpha. Abstract Text:

Hae-Ock Lee,Mioh Cho,Jung-Hwa Lee,Hyo-Sil Kim,Yungdae Yun,Hyunsook Lee,Hae-Ock Lee,Mioh Cho,Jung-Hwa Lee,Hyo-Sil Kim,Yungdae Yun,Hyunsook Lee,Hae-Ock Lee,Mioh Cho,Jung-Hwa Lee,Hyo-Sil Kim,Yungdae Yun,Hyunsook Lee,

DeltaNp63alpha is exclusively expressed in stem cells and progenitor cells of the stratified epithelia. It promotes cell proliferation by antagonizing p53 and related TAp63/TAp73. Here, we report that specific desumoylation by SUMO protease SuPr-1 provides a fine-tuning mechanism for DeltaNp63alpha repressor activity. We found that disrupting the sumoylation site compromised DeltaNp63alpha repressor activity profoundly against TAp63gamma and TAp73beta-mediated transcription activation, but not to p53-mediated transcription. We further found that SuPr-1 specifically bound to sumoylated DeltaNp63alpha and hydrolyzed SUMO. Consequently, SuPr-1 expression reduced DeltaNp63alpha repressor activity to TAp63gamma and TAp73beta, whereas p53-mediated transactivation was unaffected. Collectively, these data suggest that SuPr-1-mediated DeltaNp63alpha desumoylation elaborately regulates epithelial growth.

SuPr-1-mediated desumoylation regulates the repressor activity of DeltaNp63alpha. Publishing Authors By Initials

HO Lee,M Cho,JH Lee,HS Kim,Y Yun,H Lee,HO Lee,M Cho,JH Lee,HS Kim,Y Yun,H Lee,HO Lee,M Cho,JH Lee,HS Kim,Y Yun,H Lee,

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SuPr-1-mediated desumoylation regulates the repressor activity of DeltaNp63alpha. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: FEBS letters

VOLUME: 581

Page Numbers: 5640-4

Journal Abbreviation: FEBS Lett.

ISSN: 0014-5793

DAY: 20

MONTH: 11

YEAR: 2007

SuPr-1-mediated desumoylation regulates the repressor activity of DeltaNp63alpha. Information

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LANGUAGE: eng

NlmUniqueID: 155157

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Grant and Affiliation Information for SuPr-1-mediated desumoylation regulates the repressor activity of DeltaNp63alpha.

AFFILIATION: Department of Biological Sciences and Research Center for Functional Cellulomics, Seoul National University, Gwanak-Ku, Seoul, Republic of Korea.

Country: Netherlands

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MEDLINETA: FEBS Lett

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