Suppressor mutations that restore export of a protein with a defective signal sequence.

Suppressor mutations that restore export of a protein with a defective signal sequence. Research Abstract Details 

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Suppressor mutations that restore export of a protein with a defective signal sequence. Abstract Text:

S D Emr,S Hanley-Way,T J Silhavy,

A selection procedure is described that should allow the genetic identification of cellular components involved in the process of protein localization in Escherichia coli. This procedure makes use of mutations that alter the signal sequence of the lambda receptor protein (product of the lamB gene), and prevent export of this protein to its normal outer membrane location. Several suppressor mutations have been identified that restore export of the mutant lambda receptor protein. Mapping experiments show that the suppressor phenotype is the result of mutations in any of at least three different chromosomal loci. One class of suppressor mutations, the class containing the largest number of independent isolates, maps in the major ribosomal gene cluster, suggesting that the suppressor phenotype is the consequence of an altered ribosomal protein. This class of suppressors phenotypically suppresses all known export-defective mutations, internal to the signal sequence region of the lamB gene. These results suggest that ribosomes play an important role in the export of lambda receptor to the outer membrane.

Suppressor mutations that restore export of a protein with a defective signal sequence. Publishing Authors By Initials

SD Emr,S Hanley-Way,TJ Silhavy,

For similar genetic processes: gene expression: transcription, genetic research abstracts see: genetic processes: gene expression: transcription, genetic research

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Suppressor mutations that restore export of a protein with a defective signal sequence. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Cell

VOLUME: 23

Page Numbers: 79-88

Journal Abbreviation: Cell

ISSN: 0092-8674

DAY: 27

MONTH: Jan

YEAR: 1981

Suppressor mutations that restore export of a protein with a defective signal sequence. Information

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LANGUAGE: eng

NlmUniqueID: 413066

Suppressor mutations that restore export of a protein with a defective signal sequence. Keywords Mesh Terms:

KEYWORDS: Transcription, Genetic

MESH TERMS: genetics

Chemical & Substance for Abstract: Suppressor mutations that restore export of a protein with a defective signal sequence. Information

Substance Name: maltoporins

Registry Number: 0

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Country: UNITED STATES

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MEDLINETA: Cell

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