Suppressor cell function in psoriasis.

Suppressor cell function in psoriasis. Research Abstract Details 

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Suppressor cell function in psoriasis. Abstract Text:

Recent studies suggest that autoimmunity may play a role in the pathogenesis of psoriasis. In view of these findings, it is postulated that the immunologic defect may be associated with regulation of the immune system. A study was undertaken to determine whether a suppressor cell defect was present. Two groups of patients with active psoriasis who were receiving no therapy were selected. Peripheral blood lymphocytes were pulsed with concanavalin A, 40 microgram/cc, for 48 hours. Their ability to suppress a mixed lymphocyte reaction with both autologous and allogeneic responding cells was assessed. There was a significant decrease in suppressor activity in psoriasis patients compared with normal individuals. Although we have not demonstrated that this mechanism is implicated directly in a causal relationship to psoriasis, it nevertheless gives further support to the possible role of the immune system in the pathogenesis of psoriasis.

Suppressor cell function in psoriasis. Publishing Authors By Initials

For similar cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: t-lymphocytes: cd4-positive t-lymphocytes: t-lymphocytes, regulatory research abstracts see: cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: t-lymphocytes: cd4-positive t-lymphocytes: t-lymphocytes, regulatory research

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Suppressor cell function in psoriasis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Archives of dermatology

VOLUME: 116

Page Numbers: 51-5

Journal Abbreviation: Arch Dermatol

ISSN: 0003-987X

DAY: 17

MONTH: Jan

YEAR: 1980

Suppressor cell function in psoriasis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 372433

Suppressor cell function in psoriasis. Keywords Mesh Terms:

KEYWORDS: T-Lymphocytes, Regulatory

MESH TERMS: immunology

Chemical & Substance for Abstract: Suppressor cell function in psoriasis. Information

Substance Name: Concanavalin A

Registry Number: 11028-71-0

Grant and Affiliation Information for Suppressor cell function in psoriasis.

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Country: UNITED STATES

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MEDLINETA: Arch Dermatol

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