Suppressive effects of antiandrogens, finasteride and flutamide on development of prostatic lesions in a transgenic rat model.

Suppressive effects of antiandrogens, finasteride and flutamide on development of prostatic lesions in a transgenic rat model. Research Abstract Details 

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Suppressive effects of antiandrogens, finasteride and flutamide on development of prostatic lesions in a transgenic rat model. Abstract Text:

Y-M Cho,S Takahashi,M Asamoto,S Suzuki,M Tang,T Shirai,

Transgenic (TG) rats bearing a probasin promoter/simian virus 40 T antigen (SV40 Tag) construct were treated with antiandrogens to examine their ability to suppress prostate carcinogenesis. Finasteride and flutamide were administered to 10-week-old TG rats five times a week for 2, 5 and 7 weeks. Antiandrogen-treated prostates exhibited atrophic glandular structures with almost no expression of SV40 Tag and only weak signals for androgen receptors. Furthermore, quantitative data for ventral prostate adenocarcinomas showed significant decrease with antiandrogen treatment. Both finasteride and flutamide had the ability to suppress SV40 Tag-driven carcinogenesis through their different antiandrogenic mechanisms, suggesting that this TG model is suitable for exploring the potential of agents to inhibit prostate cancer development.Prostate Cancer and Prostatic Diseases (2007) 10, 378-383; doi:10.1038/sj.pcan.4500971; published online 24 April 2007.

Suppressive effects of antiandrogens, finasteride and flutamide on development of prostatic lesions in a transgenic rat model. Publishing Authors By Initials

YM Cho,S Takahashi,M Asamoto,S Suzuki,M Tang,T Shirai,

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Suppressive effects of antiandrogens, finasteride and flutamide on development of prostatic lesions in a transgenic rat model. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Prostate cancer and prostatic diseases

VOLUME: 10

Page Numbers: 378-83

Journal Abbreviation: Prostate Cancer Prostatic Dis.

ISSN: 1365-7852

DAY: 24

MONTH: 04

YEAR: 2007

Suppressive effects of antiandrogens, finasteride and flutamide on development of prostatic lesions in a transgenic rat model. Information

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LANGUAGE: eng

NlmUniqueID: 9815755

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AFFILIATION: 1Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Mizuho-cho, Mizuho-ku, Nagoya, Japan.

Country: England

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MEDLINETA: Prostate Cancer Prostatic Dis

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