Suppressive effects of Anoectochilus formosanus extract on osteoclast formation in vitro and bone resorption in vivo.

Suppressive effects of Anoectochilus formosanus extract on osteoclast formation in vitro and bone resorption in vivo. Research Abstract Details 

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Suppressive effects of Anoectochilus formosanus extract on osteoclast formation in vitro and bone resorption in vivo. Abstract Text:

Kikuko Masuda,Mayumi Ikeuchi,Tomoyuki Koyama,Kohji Yamaguchi,Je-Tae Woo,Tomio Nishimura,Kazunaga Yazawa,

Anoectochilus formosanus, a plant native to Taiwan, is used as a folk medicine. It was found that oral administration of A. formosanus extract (AFE) (500 mg/kg) for 4 weeks suppressed bone weight loss and trabecular bone loss in ovariectomized mice, an experimental model of osteoporosis. Although AFE at 12.5 and 25 mug/ml inhibited osteoclast formation in co-culture of osteoblasts and bone marrow cells, AFE did not inhibit the formation of osteoclast progenitor cells and preosteoclast cells in bone marrow cells and RAW264 cells. However, AFE (at 12.5 and 25 mug/ml) decreased RANKL expression. These results suggested that AFE might suppress the bone loss caused by estrogen deficiency through suppression of RANKL expression required for osteoclast formation.

Suppressive effects of Anoectochilus formosanus extract on osteoclast formation in vitro and bone resorption in vivo. Publishing Authors By Initials

K Masuda,M Ikeuchi,T Koyama,K Yamaguchi,JT Woo,T Nishimura,K Yazawa,

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Suppressive effects of Anoectochilus formosanus extract on osteoclast formation in vitro and bone resorption in vivo. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of bone and mineral metabolism

VOLUME: 26

Page Numbers: 123-9

Journal Abbreviation: J. Bone Miner. Metab.

ISSN: 0914-8779

DAY: 27

MONTH: 02

YEAR: 2008

Suppressive effects of Anoectochilus formosanus extract on osteoclast formation in vitro and bone resorption in vivo. Information

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LANGUAGE: eng

NlmUniqueID: 9436705

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AFFILIATION: Laboratory of Nutraceuticals and Functional Foods Science, Graduate School of Marine Science and Technology, Tokyo University of Marine Science and Technology, 4-5-7 Konan, Minatoku, Tokyo, 108-8477, Japan.

Country: Japan

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MEDLINETA: J Bone Miner Metab

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