Suppressive effect of paroxetine, a selective serotonin uptake inhibitor, on tetrahydrobiopterin levels and dopamine as well as serotonin turnover in the mesoprefrontal system of mice.

Suppressive effect of paroxetine, a selective serotonin uptake inhibitor, on tetrahydrobiopterin levels and dopamine as well as serotonin turnover in the mesoprefrontal system of mice. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Suppressive effect of paroxetine, a selective serotonin uptake inhibitor, on tetrahydrobiopterin levels and dopamine as well as serotonin turnover in the mesoprefrontal system of mice. Abstract Text:

Hideki Miura,Tomitsune Kitagami,Norio Ozaki,

Tetrahydrobiopterin (BH(4)) is a coenzyme of tyrosine hydroxylase (TH) and tryptophan hydroxylase (TPH), which are rate-limiting enzymes of monoamine biosynthesis. According to the monoamine hypothesis of depression, antidepressants will restore the function of the brain monoaminergic system and the BH(4) concentration. In the present study, we investigated the effect of paroxetine, a selective serotonin reuptake inhibitor (SSRI), on the BH(4) levels and dopamine (DA) and serotonin (5-HT) turnover in the mesoprefrontal system, incorporating two risk factors of depression, social isolation and acute environmental change. Male ddY mice (8W) were divided into two housing groups, i.e., group-housing (eight animals per cage; 28 days), and isolation-housing (one per cage; 28 days), being p.o.-administered paroxetine (5 or 10 mg/kg; days 15-28), and exposed to a 20-min novelty stress (day 28). The levels of BH(4), DA, homovanilic acid (HVA), 5-HT, and 5-hydroxyindoleacetic acid (5-HIAA) were measured in the prefrontal cortex and midbrain. In both the regions, novelty stress significantly increased BH(4) levels under the isolation-housing condition, whereas these levels were decreased under the group-housing condition. Thus, social isolation altered the neurochemical response to novelty stress. Paroxetine significantly decreased BH(4) levels under the isolation-housing condition, whereas decreased HVA/DA and 5-HIAA/5-HT ratios were observed under the group-housing condition. Thus, social isolation may have influenced the suppressive effects of paroxetine on BH(4) levels as well as exerted an influence on DA and 5-HT turnover. We replicated our recent findings that SSRI, fluvoxamine, suppressed BH(4) levels, as well as DA and 5-HT turnover in the mouse mesoprefrontal system.

Suppressive effect of paroxetine, a selective serotonin uptake inhibitor, on tetrahydrobiopterin levels and dopamine as well as serotonin turnover in the mesoprefrontal system of mice. Publishing Authors By Initials

H Miura,T Kitagami,N Ozaki,

For similar behavior and behavior mechanisms: behavior: behavioral symptoms: stress, psychological research abstracts see: behavior and behavior mechanisms: behavior: behavioral symptoms: stress, psychological research

PUBMED ID PMID:

MEDLINE DATE:

Suppressive effect of paroxetine, a selective serotonin uptake inhibitor, on tetrahydrobiopterin levels and dopamine as well as serotonin turnover in the mesoprefrontal system of mice. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Synapse (New York, N.Y.)

VOLUME: 61

Page Numbers: 698-706

Journal Abbreviation: Synapse

ISSN: 0887-4476

DAY: 29

MONTH: Sep

YEAR: 2007

Suppressive effect of paroxetine, a selective serotonin uptake inhibitor, on tetrahydrobiopterin levels and dopamine as well as serotonin turnover in the mesoprefrontal system of mice. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8806914

Suppressive effect of paroxetine, a selective serotonin uptake inhibitor, on tetrahydrobiopterin levels and dopamine as well as serotonin turnover in the mesoprefrontal system of mice. Keywords Mesh Terms:

KEYWORDS: Stress, Psychological

MESH TERMS: metabolism

Chemical & Substance for Abstract: Suppressive effect of paroxetine, a selective serotonin uptake inhibitor, on tetrahydrobiopterin levels and dopamine as well as serotonin turnover in the mesoprefrontal system of mice. Information

Substance Name: Paroxetine

Registry Number: 61869-08-7

Grant and Affiliation Information for Suppressive effect of paroxetine, a selective serotonin uptake inhibitor, on tetrahydrobiopterin levels and dopamine as well as serotonin turnover in the mesoprefrontal system of mice.

AFFILIATION: Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan. hmiura@med.nagoya-u.ac.jp

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Synapse

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Suppressive effect of paroxetine, a selective serotonin uptake inhibitor, on tetrahydrobiopterin levels and dopamine as well as serotonin turnover in the mesoprefrontal system of mice Related Publications

• Age of onset has limited association with body mass index at time of presentation for anorexia nervosa: Comparison of peak-onset and late-onset anorexia nervosa groups.
• Akaike causality in state space. Instantaneous causality between visual cortex in fMRI time series.
• An attenuated total reflectance far-UV spectrometer.
• Assessing the range of cervical rotation in patients with rheumatoid arthritis after atlantoaxial screw fixation using axial CT.
• Bronchoscopic removal of mucus casts in a boy with plastic bronchitis.
• Comparative biomechanical analysis of an improved novel pedicle screw with sheath and bone cement.
• Concerted inhibition of isocitrate dehydrogenase by glyoxylate plus oxalacetate.
• Cryptosporidium hominis infection of the human respiratory tract.
• Determination of surface selection rule of surface plasmon resonance near-infrared spectroscopy by using a Langmuir-Blodgett film.
• Feeding Behavior Regulation in the Fly: Effect of a Noxious Substance through the Taste and Olfactory Neurons.
• Impact of an absorbent silver-eluting dressing system on lower extremity revascularization wound complications.
• Involvement of sphingosine 1-phosphate, a platelet-derived bioactive lipid, in contraction of mesangium cells.
• Mechanism of impaired regeneration of fatty liver in mouse partial hepatectomy model.
• New approach for assessing vascular distribution within bone tumors using dynamic contrast-enhanced MRI.
• Nontraumatic subluxation of the hip after spine surgery for scoliosis in a patient with von Recklinghausen's disease.
• Phagocytotic activation of muscularis resident macrophages inhibits smooth muscle contraction in rat ileum.
• Prediction of ethylene content in melt-state random and block polypropylene by near-infrared spectroscopy and chemometrics: comparison of a new calibration transfer method with a slope/bias correction method.
• Removal of endocrine disrupting chemicals (EDCs) using low pressure reverse osmosis membrane (LPROM).
• Rho-mediated phosphorylation of focal adhesion kinase and myosin light chain in human endothelial cells stimulated with sphingosine 1-phosphate, a bioactive lysophospholipid released from activated platelets.
• Sphingosine 1-phosphate inhibits migration of RBL-2H3 cells via S1P2: cross-talk between platelets and mast cells.
• Suppressive effect of paroxetine, a selective serotonin uptake inhibitor, on tetrahydrobiopterin levels and dopamine as well as serotonin turnover in the mesoprefrontal system of mice.
• Temperature-dependent changes in hydrogen bonds in cellulose Ialpha studied by infrared spectroscopy in combination with perturbation-correlation moving-window two-dimensional correlation spectroscopy: comparison with cellulose Ibeta.
• Tumor necrosis factor-alpha and the early vein graft.
• [Can preoperative administration of H2 blocker reduce the incidence of postoperative nausea and vomiting (PONV)?]
• [Clinical application of vitamin K for hepatocellular carcinoma]
• [Drug dependence syndrome as a side effect of medical drug use]
• [Imaging techniques in multiple myeloma]
• [Myocardial infarction associated with ventricular aneurysm]
• [Remifentanil--could it open a new era in our anesthesia practice in Japan?]
• rhBMP-4 gene therapy in a juvenile canine alveolar defect model.