Suppression of reactive oxygen species by glyceraldehyde-3-phosphate dehydrogenase.

Suppression of reactive oxygen species by glyceraldehyde-3-phosphate dehydrogenase. Research Abstract Details 

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Suppression of reactive oxygen species by glyceraldehyde-3-phosphate dehydrogenase. Abstract Text:

Dongwon Baek,Yinhua Jin,Jae Cheol Jeong,Hyo-Jung Lee,Haejeong Moon,Jiyoung Lee,Dongjin Shin,Chang Ho Kang,Doh Hoon Kim,Jaesung Nam,Sang Yeol Lee,Dae-Jin Yun,

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), a classical glycolytic enzyme, is involved in cellular energy production and has important housekeeping functions. In this report, we show that a GAPDH from Arabidopsis, GAPDHa, has a novel function involved in H(2)O(2)-mediated cell death in yeast and Arabidopsis protoplasts. GAPDHa was cloned along with other plant genes that suppress Bax-induced cell death in yeast. Flow cytometry analyses with dihydrorhodamine 123 indicated that H(2)O(2) production mediated by Bax expression in yeast cells was greatly reduced when Bax was coexpressed with GAPDHa. In plants, GAPDHa transcript levels were greatly increased by H(2)O(2) treatment. Furthermore, transformation of GAPDHa into Arabidopsis protoplasts strongly suppressed heat shock-induced H(2)O(2) production and cell death. Together, our results indicate that GAPDH controls generation of H(2)O(2) by Bax and heat shock, which in turn suppresses cell death in yeast and plant cells.

Suppression of reactive oxygen species by glyceraldehyde-3-phosphate dehydrogenase. Publishing Authors By Initials

D Baek,Y Jin,JC Jeong,HJ Lee,H Moon,J Lee,D Shin,CH Kang,DH Kim,J Nam,SY Lee,DJ Yun,

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Suppression of reactive oxygen species by glyceraldehyde-3-phosphate dehydrogenase. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Phytochemistry

VOLUME: 69

Page Numbers: 333-8

Journal Abbreviation: Phytochemistry

ISSN: 0031-9422

DAY: 12

MONTH: 09

YEAR: 2007

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LANGUAGE: eng

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Grant and Affiliation Information for Suppression of reactive oxygen species by glyceraldehyde-3-phosphate dehydrogenase.

AFFILIATION: Division of Applied Life Science (BK21 program) and Environmental Biotechnology National Core Research Center, Gyeongsang National University, Jinju 660-701, Republic of Korea.

Country: United States

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MEDLINETA: Phytochemistry

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