Suppression of insulin receptor substrate 1 (IRS-1) promotes mammary tumor metastasis.

Suppression of insulin receptor substrate 1 (IRS-1) promotes mammary tumor metastasis. Research Abstract Details 

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Suppression of insulin receptor substrate 1 (IRS-1) promotes mammary tumor metastasis. Abstract Text:

Zhefu Ma,Shannon L Gibson,Maura A Byrne,Junran Zhang,Morris F White,Leslie M Shaw,

The insulin receptor substrate (IRS) proteins are cytoplasmic adaptors that organize signaling complexes downstream of activated cell surface receptors. Here, we show that IRS-1 and IRS-2, despite significant homology, play critical yet distinct functions in breast cancer, and we identify specific signaling pathways that are influenced by IRS-1 using the polyoma virus middle-T (PyV-MT) transgenic mouse model of mammary carcinoma and Irs-1 null (Irs1(-/-)) mice. The absence of Irs-1 expression enhanced metastatic spread significantly without a significant effect on primary tumor growth. Orthotopic transplant studies revealed that the increased metastatic potential of Irs1-deficient tumor cells is cell autonomous. Mammary tumors that developed in PyV-MT::Irs1(-/-) mice exhibited elevated Irs-2 function and enhanced phosphatidylinositol 3-kinase/Akt/mTor activity, suggesting that one mechanism by which Irs-1 impedes metastasis is to suppress Irs-2-dependent signaling. In support of this mechanism, reduction of Irs-2 expression in Irs1(-/-) tumor cells restored mTor signaling to wild-type levels. PyV-MT::Irs1(-/-) tumors also exhibited a significant increase in vascular endothelial growth factor expression and microvessel density, which could facilitate their dissemination. The significance of our findings for human breast cancer is heightened by our observation that Irs-1 is inactivated in wild-type, metastatic mammary tumors by serine phosphorylation. Collectively, our findings reveal that inactivation of IRS-1 enhances breast cancer metastasis and support the novel hypothesis that IRS-1 has metastasis suppressor functions for breast cancer.

Suppression of insulin receptor substrate 1 (IRS-1) promotes mammary tumor metastasis. Publishing Authors By Initials

Z Ma,SL Gibson,MA Byrne,J Zhang,MF White,LM Shaw,

For similar proteins: phosphoproteins research abstracts see: proteins: phosphoproteins research

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Suppression of insulin receptor substrate 1 (IRS-1) promotes mammary tumor metastasis. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Molecular and cellular biology

VOLUME: 26

Page Numbers: 9338-51

Journal Abbreviation: Mol. Cell. Biol.

ISSN: 0270-7306

DAY: 9

MONTH: 10

YEAR: 2006

Suppression of insulin receptor substrate 1 (IRS-1) promotes mammary tumor metastasis. Information

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LANGUAGE: eng

NlmUniqueID: 8109087

Suppression of insulin receptor substrate 1 (IRS-1) promotes mammary tumor metastasis. Keywords Mesh Terms:

KEYWORDS: Phosphoproteins

MESH TERMS: genetics

Chemical & Substance for Abstract: Suppression of insulin receptor substrate 1 (IRS-1) promotes mammary tumor metastasis. Information

Substance Name: insulin receptor substrate-1 protein

Registry Number: 0

Grant and Affiliation Information for Suppression of insulin receptor substrate 1 (IRS-1) promotes mammary tumor metastasis.

AFFILIATION: Department of Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA.

Country: United States

AGENCY: United States NIDDK

GRANT: DK38712

ACRONYM: DK

MEDLINETA: Mol Cell Biol

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