Suppression of human immunodeficiency virus type 1 replication by CD8+ cells: evidence for HLA class I-restricted triggering of cytolytic and noncytolytic mechanisms.

Suppression of human immunodeficiency virus type 1 replication by CD8+ cells: evidence for HLA class I-restricted triggering of cytolytic and noncytolytic mechanisms. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Suppression of human immunodeficiency virus type 1 replication by CD8+ cells: evidence for HLA class I-restricted triggering of cytolytic and noncytolytic mechanisms. Abstract Text:

O O Yang,S A Kalams,A Trocha,H Cao,A Luster,R P Johnson,B D Walker,

Although CD8+ lymphocytes in human immunodeficiency virus type 1 (HIV-1)-infected individuals have been demonstrated to suppress viral replication, the mechanisms of inhibition have not been defined precisely. A large body of evidence indicates that these cells act via soluble inhibitory factors, but the potential role of HLA class I-restricted cytolysis has remained controversial. Here we demonstrate that HIV-1-specific cytotoxic T lymphocytes (CTL) mediate antiviral suppression by both cytolytic and noncytolytic mechanisms. The predominant mechanism requires direct contact of CTL with the infected cells, is HLA class I restricted, and can achieve complete elimination of detectable virus in infected cell cultures. Inhibition occurs even at high multiplicities of infection or at ratios of CTL to CD4 cells as low as 1:1,000. The other mechanism is mediated by soluble inhibitory factors which are triggered in an antigen-specific and HLA-restricted fashion but then act without HLA restriction. These include MIP-1alpha, MIP-1beta, and RANTES, as well as a distinct factor(s) capable of inhibiting HIV-1 strains insensitive to these chemokines. These data indicate that HIV-1-specific CTL are potent mediators of HIV-1 suppression at cell ratios existing in vivo and demonstrate an antigen-specific trigger for CD8+ cell-derived soluble inhibitory factors. These results suggest that CTL play an important role in the observed antiviral activity of CD8+ cells from infected individuals.

Suppression of human immunodeficiency virus type 1 replication by CD8+ cells: evidence for HLA class I-restricted triggering of cytolytic and noncytolytic mechanisms. Publishing Authors By Initials

OO Yang,SA Kalams,A Trocha,H Cao,A Luster,RP Johnson,BD Walker,

For similar biological phenomena, cell phenomena, and immunity: biological phenomena: microbiologic phenomena: viral physiology: virus replication research abstracts see: biological phenomena, cell phenomena, and immunity: biological phenomena: microbiologic phenomena: viral physiology: virus replication research

PUBMED ID PMID:

MEDLINE DATE:

Suppression of human immunodeficiency virus type 1 replication by CD8+ cells: evidence for HLA class I-restricted triggering of cytolytic and noncytolytic mechanisms. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of virology

VOLUME: 71

Page Numbers: 3120-8

Journal Abbreviation: J. Virol.

ISSN: 0022-538X

DAY: 19

MONTH: Apr

YEAR: 1997

Suppression of human immunodeficiency virus type 1 replication by CD8+ cells: evidence for HLA class I-restricted triggering of cytolytic and noncytolytic mechanisms. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 113724

Suppression of human immunodeficiency virus type 1 replication by CD8+ cells: evidence for HLA class I-restricted triggering of cytolytic and noncytolytic mechanisms. Keywords Mesh Terms:

KEYWORDS: Virus Replication

MESH TERMS: immunology

Chemical & Substance for Abstract: Suppression of human immunodeficiency virus type 1 replication by CD8+ cells: evidence for HLA class I-restricted triggering of cytolytic and noncytolytic mechanisms. Information

Substance Name: macrophage inflammatory protein 1alpha r

Registry Number: 0

Grant and Affiliation Information for Suppression of human immunodeficiency virus type 1 replication by CD8+ cells: evidence for HLA class I-restricted triggering of cytolytic and noncytolytic mechanisms.

AFFILIATION: AIDS Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown 02129, USA.

Country: UNITED STATES

AGENCY: United States NIAID

GRANT: F32 AI09280-01

ACRONYM: AI

MEDLINETA: J Virol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Suppression of human immunodeficiency virus type 1 replication by CD8+ cells: evidence for HLA class I-restricted triggering of cytolytic and noncytolytic mechanisms Related Publications

• 8-Aminoquinolines: future role as antiprotozoal drugs.
• A patient with jejunostomy liberated from home intravenous therapy after 14 years; contribution of balance studies.
• A petal breakstrength meter for Arabidopsis abscission studies.
• A preliminary investigation of Ehrlichia species in ticks, humans, dogs, and capybaras from Brazil.
• Assignment of the ferriheme resonances of the high-spin forms of nitrophorins 1 and 4 by 1H NMR spectroscopy: comparison to structural data obtained from X-ray crystallography.
• Bone morphogenetic proteins act synergistically with haematopoietic cytokines in the differentiation of haematopoietic progenitors.
• Cerebral beta-amyloid angiopathy in aged squirrel monkeys.
• Characterization of Escherichia coli translesion synthesis polymerases and their accessory factors.
• Conference consensus statement: ethical and research dilemmas for fertility preservation in children treated for cancer.
• Correction of cellular zinc depletion by oral zinc supplementation in elderly subjects.
• Different forms of prolactin have opposing effects on the expression of cell cycle regulatory proteins in differentiated mammary epithelial cells.
• Document classification and searching - A neural network approach.
• Expert commentary.
• In vitro reconstitution of two essential steps in wall teichoic acid biosynthesis.
• In vivo pharmacological resultant analysis reveals noncompetitive interactions between opioid antagonists in the rat tail-withdrawal assay.
• Management of allergic problems in primary care: time for a rethink?
• Models of the cytochromes: crystal structures and EPR spectral characterization of low-spin bis-imidazole complexes of (OETPP)Fe(III) having intermediate ligand plane dihedral angles.
• NMR and EPR studies of chloroiron(III) tetraphenyl-chlorin and its complexes with imidazoles and pyridines of widely differing basicities.
• Refractory headache due to spontaneous intracranial hypotension from a CSF leak at C1-2.
• Sex differences in digit ratio (2D:4D) are disrupted in adolescents with schizotypal personality disorder: altered prenatal gonadal hormone levels as a risk factor.
• Sleep facilitates consolidation of emotional declarative memory.
• Suppression of human immunodeficiency virus type 1 replication by CD8+ cells: evidence for HLA class I-restricted triggering of cytolytic and noncytolytic mechanisms.
• Teaching ergonomics to nursing facility managers using computer-based instruction.
• The effect of baclofen on the cardiovascular system of the rat.
• The effects of acute infection on indices of zinc status.
• The impact of differential patterns of physical violence and stalking on mental health and help-seeking among women with protective orders.
• The microbiology of glue ear in Australian Aboriginal children.
• The use of dermal configurations in the diagnosis of mongolism.
• Therapeutic potential of S179D prolactin--from prostate cancer to angioproliferative disorders: the first selective prolactin receptor modulator.
• [Effects of ob genotype on early development in mice]