Suppression of hepcidin during anemia requires erythropoietic activity.

Suppression of hepcidin during anemia requires erythropoietic activity. Research Abstract Details 

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Suppression of hepcidin during anemia requires erythropoietic activity. Abstract Text:

Mihwa Pak,Miguel A Lopez,Victroia Gabayan,Tomas Ganz,Seth Rivera,

Hepcidin, the principal iron regulatory hormone, regulates the absorption of iron from the diet and the mobilization of iron from stores. Previous studies indicated that hepcidin is suppressed during anemia, a response that would appropriately increase the absorption of iron and its release from stores. Indeed, in the mouse model, hepcidin-1 was suppressed after phlebotomy or erythropoietin administration but the suppression was reversed by inhibitors of erythropoiesis. The suppression of hepcidin necessary to match iron supply to erythropoietic demand thus requires increased erythropoiesis and is not directly mediated by anemia, tissue hypoxia, or erythropoietin.

Suppression of hepcidin during anemia requires erythropoietic activity. Publishing Authors By Initials

M Pak,MA Lopez,V Gabayan,T Ganz,S Rivera,

For similar animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: mice research abstracts see: animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: mice research

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MEDLINE DATE:

Suppression of hepcidin during anemia requires erythropoietic activity. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Blood

VOLUME: 108

Page Numbers: 3730-5

Journal Abbreviation: Blood

ISSN: 0006-4971

DAY: 1

MONTH: 08

YEAR: 2006

Suppression of hepcidin during anemia requires erythropoietic activity. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7603509

Suppression of hepcidin during anemia requires erythropoietic activity. Keywords Mesh Terms:

KEYWORDS: Mice

MESH TERMS: metabolism

Chemical & Substance for Abstract: Suppression of hepcidin during anemia requires erythropoietic activity. Information

Substance Name: Iron

Registry Number: 7439-89-6

Grant and Affiliation Information for Suppression of hepcidin during anemia requires erythropoietic activity.

AFFILIATION: Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at the University of California (UCLA), Los Angeles, USA.

Country: United States

AGENCY: United States NIDDK

GRANT: R01 DK 065029

ACRONYM: DK

MEDLINETA: Blood

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