Suppression of B lymphopoiesis at a lymphoid progenitor stage in adult rabbits.

Suppression of B lymphopoiesis at a lymphoid progenitor stage in adult rabbits. Research Abstract Details 

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Suppression of B lymphopoiesis at a lymphoid progenitor stage in adult rabbits. Abstract Text:

Susan L Kalis,Shi-Kang Zhai,Pi-Chen Yam,Pamela L Witte,Katherine L Knight,

B lymphopoiesis in rabbits is robust early in ontogeny, but is arrested by 16 weeks of age at which time no proB or preB cells are found in bone marrow (BM). To determine if BM cells from adults retain B lymphopoietic potential, we transferred BM from adult green fluorescent protein (gfp) transgenic rabbits into young rabbits. We found gfp+ preB cells arising in the young recipients, indicating that BM cells from adults can differentiate into B cell precursors. We identified a population of MHCII-IL-7-binding BM cells in adults that collectively expresses Tdt, EBF and Pax5-genes known to be expressed in murine lymphoid progenitors. Upon co-culture with OP9 or OP9 delta-like 1+ stromal cells, we found that these cells both expanded in number and differentiated into B and T cell precursors, respectively, showing that early lymphoid progenitors, designated rLP for rabbit lymphoid progenitors, are present within the MHCII-IL-7-binding BM cell population. Further, IL-7 was required for rLPs to expand and differentiate into B cell precursors in vitro. The arrest of B lymphopoiesis in adults, however, is not likely due to the absence of IL-7, because the level of IL-7 transcripts was higher in BM from adults than in young rabbits. B lymphopoiesis was re-initiated in adults after sub-lethal irradiation as shown by the reappearance of B cell precursors and the presence of B cell receptor excision circles in BM. We conclude that B lymphopoiesis in adults is suppressed at a lymphoid progenitor stage (MHCII-IL-7 binding) of development.

Suppression of B lymphopoiesis at a lymphoid progenitor stage in adult rabbits. Publishing Authors By Initials

SL Kalis,SK Zhai,PC Yam,PL Witte,KL Knight,

For similar cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: t-lymphocytes research abstracts see: cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: t-lymphocytes research

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Suppression of B lymphopoiesis at a lymphoid progenitor stage in adult rabbits. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: International immunology

VOLUME: 19

Page Numbers: 801-11

Journal Abbreviation: Int. Immunol.

ISSN: 0953-8178

DAY: 13

MONTH: 05

YEAR: 2007

Suppression of B lymphopoiesis at a lymphoid progenitor stage in adult rabbits. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8916182

Suppression of B lymphopoiesis at a lymphoid progenitor stage in adult rabbits. Keywords Mesh Terms:

KEYWORDS: T-Lymphocytes

MESH TERMS: metabolism

Chemical & Substance for Abstract: Suppression of B lymphopoiesis at a lymphoid progenitor stage in adult rabbits. Information

Substance Name: DNA Nucleotidylexotransferase

Registry Number: EC 2.7.7.31

Grant and Affiliation Information for Suppression of B lymphopoiesis at a lymphoid progenitor stage in adult rabbits.

AFFILIATION: Department of Microbiology and Immunology, Neurobiology and Anatomy, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153, USA.

Country: England

AGENCY: United States NIAID

GRANT: AI50260

ACRONYM: AI

MEDLINETA: Int Immunol

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