Suppression by intrathecal BmK IT2 on rat spontaneous pain behaviors and spinal c-Fos expression induced by formalin.

Suppression by intrathecal BmK IT2 on rat spontaneous pain behaviors and spinal c-Fos expression induced by formalin. Research Abstract Details 

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Suppression by intrathecal BmK IT2 on rat spontaneous pain behaviors and spinal c-Fos expression induced by formalin. Abstract Text:

Zhan-Tao Bai,Tong Liu,Xue-Yan Pang,Zhi-Fang Chai,Yong-Hua Ji,Zhan-Tao Bai,Tong Liu,Xue-Yan Pang,Zhi-Fang Chai,Yong-Hua Ji,

The central anti-nociception of BmK IT2, a sodium channel modulator from scorpion Buthus martensi Karsh (BmK) was investigated in this study. It was found that the formalin-induced rat spontaneous flinches and spinal c-Fos expression could be significantly suppressed by intrathecal BmK IT2 pre- or post-formalin injection in a dose-dependent manner. The time course of inhibitory effect exerted by intrathecal BmK IT2 on spontaneous flinches was longer in the pre-treatment group than in post-treatment group. This was consistent with the stronger suppression on spinal c-Fos expression exerted by intrathecal BmK IT2 pre-treatment. In addition, the suppression by intrathecal BmK IT2 on formalin-induced c-Fos expression in superficial laminae was more significant than that in deeper laminae. These results indicate that BmK IT2 can induce central anti-nociceptive response and might thus be a valuable molecular tool for the understanding of pain mechanisms.

Suppression by intrathecal BmK IT2 on rat spontaneous pain behaviors and spinal c-Fos expression induced by formalin. Publishing Authors By Initials

ZT Bai,T Liu,XY Pang,ZF Chai,YH Ji,ZT Bai,T Liu,XY Pang,ZF Chai,YH Ji,

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Suppression by intrathecal BmK IT2 on rat spontaneous pain behaviors and spinal c-Fos expression induced by formalin. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Brain research bulletin

VOLUME: 73

Page Numbers: 248-53

Journal Abbreviation: Brain Res. Bull.

ISSN: 0361-9230

DAY: 5

MONTH: 04

YEAR: 2007

Suppression by intrathecal BmK IT2 on rat spontaneous pain behaviors and spinal c-Fos expression induced by formalin. Information

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LANGUAGE: eng

NlmUniqueID: 7605818

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Grant and Affiliation Information for Suppression by intrathecal BmK IT2 on rat spontaneous pain behaviors and spinal c-Fos expression induced by formalin.

AFFILIATION: College of Life Sciences, Yanan University, Yanan 716000, PR China.

Country: United States

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MEDLINETA: Brain Res Bull

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