Superiority of the Modification of Diet in Renal Disease equation over the Cockcroft-Gault equation in screening for impaired kidney function in Japanese Americans.

Superiority of the Modification of Diet in Renal Disease equation over the Cockcroft-Gault equation in screening for impaired kidney function in Japanese Americans. Research Abstract Details 

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Superiority of the Modification of Diet in Renal Disease equation over the Cockcroft-Gault equation in screening for impaired kidney function in Japanese Americans. Abstract Text:

Fernando Gerchman,Jenny Tong,Kristina M Utzschneider,Rebecca L Hull,Sakeneh Zraika,Jayalakshmi Udayasankar,Marguerite J McNeely,Dennis L Andress,Donna L Leonetti,Edward J Boyko,Wilfred Y Fujimoto,Steven E Kahn,

The Cockcroft-Gault and the Modification of Diet in Renal Disease (MDRD) Study equations have not been validated in Asian Americans with varying degrees of glucose tolerance. We compared both equations to 24-h urinary creatinine clearance, the latter as a standard measurement of glomerular filtration rate (GFR), in 398 Japanese Americans (62.1+/-5.8 years, mean+/-S.D.) who had normal glucose tolerance (NGT) (n=138), impaired glucose tolerance (IGT) (n=136) and diabetes (n=124). Although both the Cockcroft-Gault (r=0.65, P<0.001) and the MDRD (r=0.74, P<0.001) equations correlated well with creatinine clearance, the latter was significantly superior (P=0.013 between r values). Receiver operating characteristic (ROC) curve analysis showed that the area under the curve (AUC) for the MDRD equation was significantly greater than for the Cockcroft-Gault equation (AUC 0.86 versus 0.80, P=0.015) in classifying subjects as having mildly reduced GFR (<90ml/min per 1.73m(2)). However, both equations overestimated the number of individuals with decreased GFR. We conclude therefore that while the MDRD equation more accurately identifies Asians who are in the early stages of kidney disease, as for other groups, a correction term appears necessary in order to reduce the number of Asian subjects being falsely diagnosed with CKD.

Superiority of the Modification of Diet in Renal Disease equation over the Cockcroft-Gault equation in screening for impaired kidney function in Japanese Americans. Publishing Authors By Initials

F Gerchman,J Tong,KM Utzschneider,RL Hull,S Zraika,J Udayasankar,MJ McNeely,DL Andress,DL Leonetti,EJ Boyko,WY Fujimoto,SE Kahn,

For similar investigative techniques: epidemiologic methods: statistics as topic: probability: risk: risk factors research abstracts see: investigative techniques: epidemiologic methods: statistics as topic: probability: risk: risk factors research

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Superiority of the Modification of Diet in Renal Disease equation over the Cockcroft-Gault equation in screening for impaired kidney function in Japanese Americans. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Diabetes research and clinical practice

VOLUME: 77

Page Numbers: 320-6

Journal Abbreviation:

ISSN: 0168-8227

DAY: 4

MONTH: 12

YEAR: 2006

Superiority of the Modification of Diet in Renal Disease equation over the Cockcroft-Gault equation in screening for impaired kidney function in Japanese Americans. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8508335

Superiority of the Modification of Diet in Renal Disease equation over the Cockcroft-Gault equation in screening for impaired kidney function in Japanese Americans. Keywords Mesh Terms:

KEYWORDS: Risk Factors

MESH TERMS: physiopathology

Chemical & Substance for Abstract: Superiority of the Modification of Diet in Renal Disease equation over the Cockcroft-Gault equation in screening for impaired kidney function in Japanese Americans. Information

Substance Name: Creatinine

Registry Number: 60-27-5

Grant and Affiliation Information for Superiority of the Modification of Diet in Renal Disease equation over the Cockcroft-Gault equation in screening for impaired kidney function in Japanese Americans.

AFFILIATION: Division of Metabolism, Endocrinology and Nutrition, VA Puget Sound Health Care System, University of Washington, Seattle, WA 98108, USA.

Country: Ireland

AGENCY: United States NCRR

GRANT: RR-37

ACRONYM: RR

MEDLINETA: Diabetes Res Clin Pract

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