Successful treatment of recalcitrant chronic idiopathic urticaria with sulfasalazine.

Successful treatment of recalcitrant chronic idiopathic urticaria with sulfasalazine. Research Abstract Details 

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Successful treatment of recalcitrant chronic idiopathic urticaria with sulfasalazine. Abstract Text:

Laura Y McGirt,Kavitha Vasagar,Laura M Gober,Sarbjit S Saini,Lisa A Beck,

BACKGROUND: Antihistamines are the standard treatment for chronic idiopathic urticaria (CIU). For patients whose urticaria is unresponsive to antihistamines, the treatment options are limited. During the previous decade, there have been several case reports demonstrating success with sulfasalazine therapy. In this article, we present a case series evaluating sulfasalazine therapy for antihistamine-unresponsive CIU. OBSERVATIONS: Nineteen patients with antihistamine-unresponsive CIU were treated with sulfasalazine between 2002 and 2005. During sulfasalazine therapy, 14 patients (74%) reported significant improvement, 4 patients (21%) reported minimal improvement but were not satisfied with their symptom relief, and 1 patient (5%) reported a worsening of symptoms. Of the 13 patients who required systemic steroids to control their urticaria, all were able to reduce or discontinue steroid use during sulfasalazine therapy. Although 7 patients (37%) had adverse effects (eg, nausea, headache, mild or transient leukopenia, and transaminitis) that were thought to be caused by the use of sulfasalazine, they all kept taking the drug. CONCLUSIONS: This case series demonstrates that sulfasalazine can be a successful and safe treatment option for patients with CIU who have not responded adequately to treatment with antihistamines. Sulfasalazine was steroid sparing in all subjects who were steroid dependent.

Successful treatment of recalcitrant chronic idiopathic urticaria with sulfasalazine. Publishing Authors By Initials

LY McGirt,K Vasagar,LM Gober,SS Saini,LA Beck,

For similar skin and connective tissue diseases: skin diseases: skin diseases, vascular: urticaria research abstracts see: skin and connective tissue diseases: skin diseases: skin diseases, vascular: urticaria research

PUBMED ID PMID:

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Successful treatment of recalcitrant chronic idiopathic urticaria with sulfasalazine. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Archives of dermatology

VOLUME: 142

Page Numbers: 1337-42

Journal Abbreviation:

ISSN: 0003-987X

DAY: 3

MONTH: Oct

YEAR: 2006

Successful treatment of recalcitrant chronic idiopathic urticaria with sulfasalazine. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 372433

Successful treatment of recalcitrant chronic idiopathic urticaria with sulfasalazine. Keywords Mesh Terms:

KEYWORDS: Urticaria

MESH TERMS: pathology

Chemical & Substance for Abstract: Successful treatment of recalcitrant chronic idiopathic urticaria with sulfasalazine. Information

Substance Name: Sulfasalazine

Registry Number: 599-79-1

Grant and Affiliation Information for Successful treatment of recalcitrant chronic idiopathic urticaria with sulfasalazine.

AFFILIATION: Department of Dermatology, Johns Hopkins Medical Institutions, Baltimore, MD, USA.

Country: United States

AGENCY: United States NIAID

GRANT: AI50024

ACRONYM: AI

MEDLINETA: Arch Dermatol

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