Successful treatment of a child with t(15;19)-positive tumor.

Successful treatment of a child with t(15;19)-positive tumor. Research Abstract Details 

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Successful treatment of a child with t(15;19)-positive tumor. Abstract Text:

Fredrik Mertens,Thomas Wiebe,Catharina Adlercreutz,Nils Mandahl,Christopher A French,Fredrik Mertens,Thomas Wiebe,Catharina Adlercreutz,Nils Mandahl,Christopher A French,

A subset of poorly differentiated carcinomas is characterized by the translocation t(15;19)(q13;p13), resulting in a BRD4/NUT fusion gene. Typically, this tumor affects children or young adults, with a predilection for midline head and neck or thoracic structures. The clinical course is invariably fatal, in spite of intensive chemotherapy and radiotherapy. We here present the successful treatment of a 10-year-old boy who presented with a BRD4/NUT-positive undifferentiated tumor in the iliac bone. The patient was selected for combined modality therapy, and has remained in complete continuous remission for close to 13 years. The findings show that t(15;19)-BRD4/NUT-positive tumors may arise in locations more typical for other pediatric tumors, such as Ewing sarcoma, and that they not always display epithelial differentiation. More importantly, our results also demonstrate that at least some patients with t(15;19)-positive tumors may be successfully treated.

Successful treatment of a child with t(15;19)-positive tumor. Publishing Authors By Initials

F Mertens,T Wiebe,C Adlercreutz,N Mandahl,CA French,F Mertens,T Wiebe,C Adlercreutz,N Mandahl,CA French,

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Successful treatment of a child with t(15;19)-positive tumor. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Pediatric blood & cancer

VOLUME: 49

Page Numbers: 1015-7

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ISSN: 1545-5009

DAY: 22

MONTH: Dec

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 101186624

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Grant and Affiliation Information for Successful treatment of a child with t(15;19)-positive tumor.

AFFILIATION: Department of Clinical Genetics, Lund University Hospital, Lund, Sweden. fredrik.mertens@med.lu.se

Country: United States

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MEDLINETA: Pediatr Blood Cancer

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