Successful 2-year-long remission following repeated salvage surgery in a patient with chemotherapy-resistant metastatic nonseminomatous germ cell tumor.

Successful 2-year-long remission following repeated salvage surgery in a patient with chemotherapy-resistant metastatic nonseminomatous germ cell tumor. Research Abstract Details 

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Successful 2-year-long remission following repeated salvage surgery in a patient with chemotherapy-resistant metastatic nonseminomatous germ cell tumor. Abstract Text:

Hideki Takeshita,Junji Yonese,Yasuhisa Fujii,Satoru Kawakami,Yoshinobu Komai,Yuhei Ohkubo,Shinya Yamamoto,Yuichi Ishikawa,Yasuyuki Seto,Shigekazu Ohyama,Iwao Fukui,

A 34 year-old man with a diagnosis of nonseminomatous testicular cancer with retroperitoneal lymph node metastasis (T1N3M0S2, stage IIIb; intermediate prognosis, made after right inguinal orchiectomy was performed) was referred to our hospital after having had a total of eight courses of systemic chemotherapy and external-beam radiotherapy to the retroperitoneal region in the previous 1 year. His serum alpha-fetoprotein (AFP) level remained elevated. Two courses of paclitaxel, etoposide, and cisplatin combined chemotherapy (TEP; paclitaxel 120 mg/m(2) day 1, etoposide 80 mg/m(2) days 2-5, cisplatin 20 mg/m(2) days 2-5) failed to normalize the AFP level. During the following 2 years he underwent salvage surgery four times; infrarenal retroperitoneal lymph node dissection (RPLND), left neck lymph node dissection, thoracic duct excision, and suprarenal RPLND. Viable cancer cells were found in all surgically resected specimens, except for the neck lymph node specimen. The serum AFP level was normalized and he has been well without relapse for 2 years after the last surgery. The present case suggests that repeated salvage surgery may be beneficial in selected patients with a chemotherapy-resistant metastatic germ cell tumor.

Successful 2-year-long remission following repeated salvage surgery in a patient with chemotherapy-resistant metastatic nonseminomatous germ cell tumor. Publishing Authors By Initials

H Takeshita,J Yonese,Y Fujii,S Kawakami,Y Komai,Y Ohkubo,S Yamamoto,Y Ishikawa,Y Seto,S Ohyama,I Fukui,

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Successful 2-year-long remission following repeated salvage surgery in a patient with chemotherapy-resistant metastatic nonseminomatous germ cell tumor. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: International journal of clinical oncology / Japan

VOLUME: 12

Page Numbers: 485-7

Journal Abbreviation: Int. J. Clin. Oncol.

ISSN: 1341-9625

DAY: 21

MONTH: 12

YEAR: 2007

Successful 2-year-long remission following repeated salvage surgery in a patient with chemotherapy-resistant metastatic nonseminomatous germ cell tumor. Information

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LANGUAGE: eng

NlmUniqueID: 9616295

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Grant and Affiliation Information for Successful 2-year-long remission following repeated salvage surgery in a patient with chemotherapy-resistant metastatic nonseminomatous germ cell tumor.

AFFILIATION: Department of Urology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan, take_uro@ybb.ne.jp.

Country: Japan

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MEDLINETA: Int J Clin Oncol

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