Subventricular zone-derived neuroblast migration to the olfactory bulb is modulated by matrix remodelling.

Subventricular zone-derived neuroblast migration to the olfactory bulb is modulated by matrix remodelling. Research Abstract Details 

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Subventricular zone-derived neuroblast migration to the olfactory bulb is modulated by matrix remodelling. Abstract Text:

Serena Bovetti,Patrizia Bovolin,Isabelle Perroteau,Adam C Puche,

In the rodent brain neural progenitor cells are born in the subventricular zone and migrate along a pathway called the rostral migratory stream (RMS) into the olfactory bulb where they differentiate into several classes of interneurones. In the adult, tangential migration in the RMS takes place in 'chains' of cells contained within glial tubes. In contrast, neonatal neuroblasts along the RMS lack these defined glial tubes and chains, migrating instead as individual cells. Time-lapse confocal microscopy of neuroblasts at each of these ages shows that individual cells migrate in a saltatory manner with bursts of high speed followed by periods of slower speed. Tangential migration within a glial tube is 20% faster than migration as individual cells. Neuroblasts may also interact and modify the extracellular matrix during migration through expression of a family of proteins, the matrix metalloproteinases (MMPs). MMPs are present and active along the subventricular zone-olfactory bulb pathway. In the presence of inhibitors of MMPs, neuroblast migration rates were reduced only when cells migrate individually. Chain migration in the adult was unaffected by MMP inhibitors. Taken together, these data suggest that MMPs only influence migration as individual cells and not as chains.

Subventricular zone-derived neuroblast migration to the olfactory bulb is modulated by matrix remodelling. Publishing Authors By Initials

S Bovetti,P Bovolin,I Perroteau,AC Puche,

For similar cells: stem cells research abstracts see: cells: stem cells research

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Subventricular zone-derived neuroblast migration to the olfactory bulb is modulated by matrix remodelling. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The European journal of neuroscience

VOLUME: 25

Page Numbers: 2021-33

Journal Abbreviation:

ISSN: 0953-816X

DAY: 3

MONTH: Apr

YEAR: 2007

Subventricular zone-derived neuroblast migration to the olfactory bulb is modulated by matrix remodelling. Information

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LANGUAGE: eng

NlmUniqueID: 8918110

Subventricular zone-derived neuroblast migration to the olfactory bulb is modulated by matrix remodelling. Keywords Mesh Terms:

KEYWORDS: Stem Cells

MESH TERMS: physiology

Chemical & Substance for Abstract: Subventricular zone-derived neuroblast migration to the olfactory bulb is modulated by matrix remodelling. Information

Substance Name: Matrix Metalloproteinases

Registry Number: EC 3.4.24.-

Grant and Affiliation Information for Subventricular zone-derived neuroblast migration to the olfactory bulb is modulated by matrix remodelling.

AFFILIATION: Department of Human and Animal Biology, University of Torino, Torino, Italy.

Country: France

AGENCY: United States NIDCD

GRANT: DC05739

ACRONYM: DC

MEDLINETA: Eur J Neurosci

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