Subunit-subunit interactions in the human 26S proteasome.

Subunit-subunit interactions in the human 26S proteasome. Research Abstract Details 

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Subunit-subunit interactions in the human 26S proteasome. Abstract Text:

Chuan Chen,Caoxin Huang,Shouhui Chen,Jie Liang,Wenbo Lin,Guifen Ke,Hongxin Zhang,Bing Wang,Jian Huang,Zeguang Han,Lixin Ma,Keke Huo,Xiaoming Yang,Pengyuan Yang,Fuchu He,Tao Tao,Chuan Chen,Caoxin Huang,Shouhui Chen,Jie Liang,Wenbo Lin,Guifen Ke,Hongxin Zhang,Bing Wang,Jian Huang,Zeguang Han,Lixin Ma,Keke Huo,Xiaoming Yang,Pengyuan Yang,Fuchu He,Tao Tao,

Ubiquitin-dependent proteolysis is mediated by the proteasome. To understand the structure and function of the human 26S proteasome, we cloned complete ORFs of 32 human proteasome subunits and conducted a yeast two-hybrid analysis of their interactions with each other. We observed that there are 114 interacting-pairs in the human 26S proteasome. About 10% (11/114) of these interacting-pairs was confirmed by the GST-pull down analysis. Among these observed interacting subunits, 58% (66/114) are novel and the rest 42% (48/114) has been reported previously in human or in other species. We observed new interactions between the 19S regulatory particle and the beta-rings of the 20S catalytic particle and therefore proposed a modified model of the 26S proteasome.

Subunit-subunit interactions in the human 26S proteasome. Publishing Authors By Initials

C Chen,C Huang,S Chen,J Liang,W Lin,G Ke,H Zhang,B Wang,J Huang,Z Han,L Ma,K Huo,X Yang,P Yang,F He,T Tao,C Chen,C Huang,S Chen,J Liang,W Lin,G Ke,H Zhang,B Wang,J Huang,Z Han,L Ma,K Huo,X Yang,P Yang,F He,T Tao,

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Subunit-subunit interactions in the human 26S proteasome. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Proteomics

VOLUME: 8

Page Numbers: 508-20

Journal Abbreviation: Proteomics

ISSN: 1615-9853

DAY: 2

MONTH: Feb

YEAR: 2008

Subunit-subunit interactions in the human 26S proteasome. Information

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LANGUAGE: eng

NlmUniqueID: 101092707

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Grant and Affiliation Information for Subunit-subunit interactions in the human 26S proteasome.

AFFILIATION: Key Laboratory for Cell Biology and Tumor Cell Engineering, the Ministry of Education, School of Life Sciences, Xiamen University, Xiamen, China.

Country: Germany

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MEDLINETA: Proteomics

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