Subtype IV of the BK polyomavirus is prevalent in East Asia.

Subtype IV of the BK polyomavirus is prevalent in East Asia. Research Abstract Details 

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Subtype IV of the BK polyomavirus is prevalent in East Asia. Abstract Text:

Q Chen,H-Y Zheng,S Zhong,H Ikegaya,H-X He,W Wei,Y-Y He,N Kobayashi,T Honjo,T Takasaka,S Takahashi,T Kitamura,Y Yogo,Q Chen,H-Y Zheng,S Zhong,H Ikegaya,H-X He,W Wei,Y-Y He,N Kobayashi,T Honjo,T Takasaka,S Takahashi,T Kitamura,Y Yogo,Q Chen,H-Y Zheng,S Zhong,H Ikegaya,H-X He,W Wei,Y-Y He,N Kobayashi,T Honjo,T Takasaka,S Takahashi,T Kitamura,Y Yogo,

BK polyomavirus (BKV) is ubiquitous in human populations, infecting children asymptomatically and then persisting in the kidney. Using either serological or genotyping methods, BKV isolates have been classified into four subtypes (I-IV), with subtype I mainly detected in all countries studied so far. To elucidate the subtype of BKV prevalent in East Asia, we examined BKV-positive urine samples collected from immunocompetent elderly patients in Mongolia, Northeast China, Northwest China, Southeast China, Southwest China, Vietnam and Japan. The 287-bp typing region of the viral genome in each of these samples was PCR-amplified and sequenced, and a phylogenetic tree was constructed. According to the tree, BKV isolates in East Asia were unambiguously classified into subtype I or IV (subtypes II and III were not detected). In Japan, subtype I was mainly detected and subtype IV was rare, whereas in the other regions subtype IV was detected frequently, at rates ranging from 24 to 100%. Thus, East Asia (excluding Japan) is a region in which subtype-IV BKV is prevalent, a finding that requires the view of the geographic distribution of BKV subtypes to be revised. Furthermore, we present evidence that the immunological states of urine donors do not affect the pattern of BKV subtypes.

Subtype IV of the BK polyomavirus is prevalent in East Asia. Publishing Authors By Initials

Q Chen,HY Zheng,S Zhong,H Ikegaya,HX He,W Wei,YY He,N Kobayashi,T Honjo,T Takasaka,S Takahashi,T Kitamura,Y Yogo,Q Chen,HY Zheng,S Zhong,H Ikegaya,HX He,W Wei,YY He,N Kobayashi,T Honjo,T Takasaka,S Takahashi,T Kitamura,Y Yogo,Q Chen,HY Zheng,S Zhong,H Ikegaya,HX He,W Wei,YY He,N Kobayashi,T Honjo,T Takasaka,S Takahashi,T Kitamura,Y Yogo,

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Subtype IV of the BK polyomavirus is prevalent in East Asia. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Archives of virology

VOLUME: 151

Page Numbers: 2419-29

Journal Abbreviation: Arch. Virol.

ISSN: 0304-8608

DAY: 10

MONTH: 07

YEAR: 2006

Subtype IV of the BK polyomavirus is prevalent in East Asia. Information

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LANGUAGE: eng

NlmUniqueID: 7506870

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AFFILIATION: Department of Urology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.

Country: Austria

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MEDLINETA: Arch Virol

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