Suberoyl bishydroxamic acid inhibits cellular proliferation by inducing cell cycle arrest in carcinoid cancer cells.

Suberoyl bishydroxamic acid inhibits cellular proliferation by inducing cell cycle arrest in carcinoid cancer cells. Research Abstract Details 

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Suberoyl bishydroxamic acid inhibits cellular proliferation by inducing cell cycle arrest in carcinoid cancer cells. Abstract Text:

David Yu Greenblatt,Max Cayo,Li Ning,Renata Jaskula-Sztul,Megan Haymart,Muthusamy Kunnimalaiyaan,Herbert Chen,David Yu Greenblatt,Max Cayo,Li Ning,Renata Jaskula-Sztul,Megan Haymart,Muthusamy Kunnimalaiyaan,Herbert Chen,David Yu Greenblatt,Max Cayo,Li Ning,Renata Jaskula-Sztul,Megan Haymart,Muthusamy Kunnimalaiyaan,Herbert Chen,

Carcinoid cancers arise from the neuroendocrine cell system of the gastrointestinal tract, lungs, and other organs. Hepatic metastases are common, and patients often suffer from endocrinopathies secondary to tumor secretion of various hormones and peptides. As complete surgical resection is often not possible because of widespread disease, new therapeutic and palliative treatments are needed. In this study, we characterized the effects of suberoyl bishydroxamic acid (SBHA), a histone deacetylase inhibitor, on the growth and neuroendocrine phenotype of carcinoid cancer cells. SBHA treatment of human gastrointestinal and pulmonary carcinoid cancer cells resulted in a dose-dependent inhibition of cell proliferation. Western blot analysis showed a decrease in cyclin D1 and an increase in p21 and p27, indicating that the mechanism of this growth inhibition is cell cycle arrest. Furthermore, SBHA treatment suppressed two neuroendocrine tumor markers, chromogranin A and achaete-scute complex-like 1. These changes in the growth and neuroendocrine phenotype of carcinoid cells were associated with activation of the Notch1 signaling cascade. We conclude that SBHA shows promise as a potential anticancer agent for the treatment of patients with advanced carcinoid tumor disease.

Suberoyl bishydroxamic acid inhibits cellular proliferation by inducing cell cycle arrest in carcinoid cancer cells. Publishing Authors By Initials

DY Greenblatt,M Cayo,L Ning,R Jaskula-Sztul,M Haymart,M Kunnimalaiyaan,H Chen,DY Greenblatt,M Cayo,L Ning,R Jaskula-Sztul,M Haymart,M Kunnimalaiyaan,H Chen,DY Greenblatt,M Cayo,L Ning,R Jaskula-Sztul,M Haymart,M Kunnimalaiyaan,H Chen,

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Suberoyl bishydroxamic acid inhibits cellular proliferation by inducing cell cycle arrest in carcinoid cancer cells. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of gastrointestinal surgery : official jou

VOLUME: 11

Page Numbers: 1515-20; discussion 1520

Journal Abbreviation: J. Gastrointest. Surg.

ISSN: 1091-255X

DAY: 15

MONTH: 09

YEAR: 2007

Suberoyl bishydroxamic acid inhibits cellular proliferation by inducing cell cycle arrest in carcinoid cancer cells. Information

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LANGUAGE: eng

NlmUniqueID: 9706084

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Grant and Affiliation Information for Suberoyl bishydroxamic acid inhibits cellular proliferation by inducing cell cycle arrest in carcinoid cancer cells.

AFFILIATION: Endocrine Surgery Research Laboratories, Department of Surgery, University of Wisconsin, Madison, WI 53792, USA.

Country: United States

AGENCY: United States NIDDK

GRANT: DK066169

ACRONYM: DK

MEDLINETA: J Gastrointest Surg

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