Subcutaneous vitamin E ameliorates liver injury in an in vivo model of steatocholestasis.

Subcutaneous vitamin E ameliorates liver injury in an in vivo model of steatocholestasis. Research Abstract Details 

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Subcutaneous vitamin E ameliorates liver injury in an in vivo model of steatocholestasis. Abstract Text:

Several genetic metabolic liver diseases share the pathological features of combined steatosis and cholestasis, or steatocholestasis. The aims of this study were to develop and characterize an in vivo model for steatocholestasis and to evaluate the effects of an antioxidant treatment on liver injury, oxidative stress, and mitochondrial perturbations in this model. Obese and lean Zucker rats received intravenous (IV) injections of glycochenodeoxycholic acid (GCDC) and were killed 4 hours later. Liver enzymes were measured; the liver histology was assessed, and hepatic mitochondria were analyzed for mitochondrial lipid peroxidation. In separate experiments, rats received daily injections of subcutaneous (SQ) vitamin E before GCDC infusion. Bile acid-induced injury (serum AST and ALT and liver histology) was more severe in the obese rats than in the lean rats, characterized predominantly by extensive cell necrosis with minimal evidence of apoptosis. SQ vitamin E provided significant protection against IV GCDC-induced hepatic injury, in vitro GCDC-induced permeability transition, and cytochrome C and apoptosis-inducing factor release from isolated mitochondria. CONCLUSION: Steatosis sensitizes the liver to bile acid-induced necrotic hepatocyte injury, which is responsive to vitamin E therapy.

Subcutaneous vitamin E ameliorates liver injury in an in vivo model of steatocholestasis. Publishing Authors By Initials

For similar polycyclic compounds: steroids: secosteroids: vitamin d research abstracts see: polycyclic compounds: steroids: secosteroids: vitamin d research

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Subcutaneous vitamin E ameliorates liver injury in an in vivo model of steatocholestasis. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Hepatology (Baltimore, Md.)

VOLUME: 46

Page Numbers: 485-95

Journal Abbreviation: Hepatology

ISSN: 0270-9139

DAY: 3

MONTH: Aug

YEAR: 2007

Subcutaneous vitamin E ameliorates liver injury in an in vivo model of steatocholestasis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8302946

Subcutaneous vitamin E ameliorates liver injury in an in vivo model of steatocholestasis. Keywords Mesh Terms:

KEYWORDS: Vitamin D

MESH TERMS: administration & dosage

Chemical & Substance for Abstract: Subcutaneous vitamin E ameliorates liver injury in an in vivo model of steatocholestasis. Information

Substance Name: Alanine Transaminase

Registry Number: EC 2.6.1.2

Grant and Affiliation Information for Subcutaneous vitamin E ameliorates liver injury in an in vivo model of steatocholestasis.

AFFILIATION: Pediatric Liver Center and Liver Transplantation Program, Section of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Colorado at Denver Health Sciences Center, Denver, CO, USA.

Country: United States

AGENCY: United States NIDDK

GRANT: R01DK38446

ACRONYM: DK

MEDLINETA: Hepatology

REFSOURCE: Hepatology. 2007 Aug;46(2):288-90

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