Subchronic toxicity study of 3-monochloropropane-1,2-diol administered by drinking water to B6C3F1 mice.

Subchronic toxicity study of 3-monochloropropane-1,2-diol administered by drinking water to B6C3F1 mice. Research Abstract Details 

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Subchronic toxicity study of 3-monochloropropane-1,2-diol administered by drinking water to B6C3F1 mice. Abstract Text:

Wan-Seob Cho,Beom Seok Han,Hakyung Lee,Cheulkyu Kim,Ki Taek Nam,Kidae Park,Mina Choi,Sung Jun Kim,Seung Hee Kim,Jayoung Jeong,Dong Deuk Jang,

3-Monochloropropane-1,2-diol (3-MCPD) is a food processing contaminant in a wide range of foods and ingredients and is a suspected cause of cancer. In this study, the 13-week toxicity of 3-MCPD was examined in B6C3F1 mice (10/sex/group) administered 3-MCPD doses of 0, 5, 25, 100, 200 and 400ppm dissolved in their drinking water over a 13-week period. All the mice survived to the end of study. The mean body weight gains in the males and females given 400ppm were significantly lower than those of the controls. The relative kidney weights of the males and females given 200 and 400ppm were significantly higher than those of the controls without any corresponding histopathological changes. The sperm motility was lower in the 400ppm group than the control, and there was a significant increase in the incidence of germinal epithelium degeneration in the 200 and 400ppm groups. A delayed total estrus cycle length was observed in the 400ppm group without any histopathological changes. Based on these results, the target organ was determined to be kidney, testis, and ovary. The no-observed-adverse-effect level (NOAEL) was found to be 100ppm (18.05mg/kg/day for males and 15.02mg/kg/day for females).

Subchronic toxicity study of 3-monochloropropane-1,2-diol administered by drinking water to B6C3F1 mice. Publishing Authors By Initials

WS Cho,BS Han,H Lee,C Kim,KT Nam,K Park,M Choi,SJ Kim,SH Kim,J Jeong,DD Jang,

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Subchronic toxicity study of 3-monochloropropane-1,2-diol administered by drinking water to B6C3F1 mice. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Food and chemical toxicology : an international jo

VOLUME: 46

Page Numbers: 1666-73

Journal Abbreviation: Food Chem. Toxicol.

ISSN: 0278-6915

DAY: 20

MONTH: 01

YEAR: 2008

Subchronic toxicity study of 3-monochloropropane-1,2-diol administered by drinking water to B6C3F1 mice. Information

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LANGUAGE: eng

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AFFILIATION: Division of Toxicologic Pathology, Department of Toxicological Research, Korea Food and Drug Administration, National Institute of Toxicological Research, Korea FDA, 5 Nokbun-dong, Eunpyung-ku, Seoul 122-704, Republic of Korea.

Country: England

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MEDLINETA: Food Chem Toxicol

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