Subcellular changes of essential metal shown by in-air micro-PIXE in oral cadmium-exposed mice.

Subcellular changes of essential metal shown by in-air micro-PIXE in oral cadmium-exposed mice. Research Abstract Details 

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Subcellular changes of essential metal shown by in-air micro-PIXE in oral cadmium-exposed mice. Abstract Text:

Kyoumi Nakazato,Takeaki Nagamine,Keij Suzuki,Takahiko Kusakabe,H D Moon,Masakazu Oikawa,Takuro Sakai,Kazuo Arakawa,Kyoumi Nakazato,Takeaki Nagamine,Keij Suzuki,Takahiko Kusakabe,H D Moon,Masakazu Oikawa,Takuro Sakai,Kazuo Arakawa,

To clarify the relation of essential metals to cadmium (Cd) toxicity, we evaluated metallothionein expression and analyzed the subcellular distribution of essential metals using in-air micro-Particle-Induced X-ray Emission (PIXE). Four mice were dosed orally with 100 mg/L of Cd in drinking water for 1.5 or 2 years. Frozen samples of organs were used for micro-PIXE analysis and formalin-fixed samples were used for metallothionein staining. Immunohistochemically, metallothionein induction by 1.5y-Cd exposure was higher in the renal cortex than in the liver. Metallothionein expression was reduced after 2y-Cd administration compared to the 1.5y-Cd-exposed mice. Cd-induced tissue damage became marked in the 2y-Cd-exposed mice compared to the 1.5y-Cd-exposed mice, in which nephrotoxicity was more prominent than hepatotoxicity. Cd yield was higher in the renal cortex of the 2y-Cd-exposed mouse than in that of the 1.5y-Cd-exposed mouse, whereas no such increasing tendency was found in the liver. Compared to the control, the Cd-exposed mice markedly accumulated zinc in the liver and renal cortex. In the Cd-exposed mice, iron was mildly accumulated in the renal cortex and was slightly deprived in the liver. Elemental maps showed that a large amount of Cd was spatially combined with zinc in the 1.5y-Cd mouse. Free Cd became abundant in the 2y-Cd-exposed mouse. In addition, a small amount of Cd was colocalized with iron. The data suggest that zinc may contribute to protect against oral-administrated Cd toxicity, and impaired induction of MT may participate in hepato-nephrotoxicity of the 2y-Cd-exposed mouse.

Subcellular changes of essential metal shown by in-air micro-PIXE in oral cadmium-exposed mice. Publishing Authors By Initials

K Nakazato,T Nagamine,K Suzuki,T Kusakabe,HD Moon,M Oikawa,T Sakai,K Arakawa,K Nakazato,T Nagamine,K Suzuki,T Kusakabe,HD Moon,M Oikawa,T Sakai,K Arakawa,

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Subcellular changes of essential metal shown by in-air micro-PIXE in oral cadmium-exposed mice. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Biometals : an international journal on the role o

VOLUME: 21

Page Numbers: 83-91

Journal Abbreviation: Biometals

ISSN: 0966-0844

DAY: 28

MONTH: 03

YEAR: 2007

Subcellular changes of essential metal shown by in-air micro-PIXE in oral cadmium-exposed mice. Information

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LANGUAGE: eng

NlmUniqueID: 9208478

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AFFILIATION: School of Health Sciences, Faculty of Medicine, Gunma University, 3-39-15 Shouwa-machi, Maebashi, Gunma, 371-8514, Japan, nkyoumi@health.gunma-u.ac.jp.

Country: Netherlands

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MEDLINETA: Biometals

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