Study on the relationship between opioid receptors and fetal distress.

Study on the relationship between opioid receptors and fetal distress. Research Abstract Details 

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Study on the relationship between opioid receptors and fetal distress. Abstract Text:

Dian Hu,Hang Gu,Xinru Hong,Yan Liu,Chenghai Wang,Liping Cao,Ping Li,

OBJECTIVE: To evaluate the role of opioid receptors in the fatal distress. METHODS: Pregnant near-term rabbits were given an intravenous dose of normal saline solution or the opiate antagonist beta-FNA and ICI and then asphyxiated. The rabbit fetus were delivered by cesarean section and evaluated for respiration, heart beat, color, muscle tone, and response to stimulation at 1, 5, 10, 15, and 30 minutes of age. RESULTS: The FNA-treated pups (6.8 +/- 1.7) and the ICI-treated pups (4.9 +/- 0.7) had significantly better scores than the saline-treated pups (2.5 +/- 1.1) and the fetal distress group (2.1 +/- 1.0, P < 0.01 and P < 0.05); there was no statistical difference between the saline group and the non treated pups (P > 0.05). The Apgar scores in ICI group, saline group, and fetal distress group were significantly decreased than that in control group (P < 0.01 and P < 0.05); Scores of all five subjects could be raised markedly in FNA group, there was no significant difference in the FNA-treated pups and the control group (P > 0.05). CONCLUSIONS: These results suggested that both mu- and delta- receptors participated in conducting the endogenous opioid peptides effect, it was associated with the pathophysiological changes in fetal distress; mu- receptor was much more important between the two.

Study on the relationship between opioid receptors and fetal distress. Publishing Authors By Initials

D Hu,H Gu,X Hong,Y Liu,C Wang,L Cao,P Li,

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Study on the relationship between opioid receptors and fetal distress. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua fu chan ke za zhi

VOLUME: 37

Page Numbers: 395-7

Journal Abbreviation: Zhonghua Fu Chan Ke Za Zhi

ISSN: 0529-567X

DAY: 4

MONTH: Jul

YEAR: 2002

Study on the relationship between opioid receptors and fetal distress. Information

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LANGUAGE: eng

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AFFILIATION: Department of Obstetrics and Gynecology, Affiliated Changzheng Hospital of the Second Military Medical University, Shanghai 200003, China.

Country: China

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MEDLINETA: Zhonghua Fu Chan Ke Za Zhi

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