[Study on the genic polymorphism of HLA-DRB1 in a population in the north of China]

[Study on the genic polymorphism of HLA-DRB1 in a population in the north of China] Research Abstract Details 

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[Study on the genic polymorphism of HLA-DRB1 in a population in the north of China] Abstract Text:

Dan Li,Hai-yan Liu,Bin Xi,Yan Yu,

OBJECTIVE: To investigate at the DNA level the polymorphism of HLA-DRB1 gene in Han population in Beijing of China. METHODS: This study was conducted in the Hans in Beijing. A total of 2810 normal and unrelated neonates were analyzed and subjected to HLA-DRB1 low resolution typing, and from among them 217 neonates were randomly selected for DRB1 high resolution typing by polymerase chain reaction-sequence specific primers technique. RESULTS: Fourteen HLA-DRB1 specificity and 39 alleles were found with HLA-DRB1 *09012, *1501, *07011, *08032 as the most common genes. Their gene frequencies and allelic distributions were compared to those observed in other ethnic populations. CONCLUSION: The results showed the characteristic of HLA-DRB1 distribution, and provided more comprehensive and accurate gene data that may serve as normal reference values for the population in Beijing, China.

[Study on the genic polymorphism of HLA-DRB1 in a population in the north of China] Publishing Authors By Initials

D Li,HY Liu,B Xi,Y Yu,

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[Study on the genic polymorphism of HLA-DRB1 in a population in the north of China] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua yi xue yi chuan xue za zhi = Zhonghua yix

VOLUME: 20

Page Numbers: 325-7

Journal Abbreviation: Zhonghua Yi Xue Yi Chuan Xue Z

ISSN: 1003-9406

DAY: 6

MONTH: Aug

YEAR: 2003

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LANGUAGE: chi

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AFFILIATION: HLA Laboratory, People's Hospital and Institute of Hematology, Beijing University, Beijing, 100044 PR China. lee-adan@Yahoo.com.cn

Country: China

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MEDLINETA: Zhonghua Yi Xue Yi Chuan Xue Z

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