[Study on the detection of inv(16) in acute myelomonocytic leukemia (M4) by flucorescence in situ hybridization method]

[Study on the detection of inv(16) in acute myelomonocytic leukemia (M4) by flucorescence in situ hybridization method] Research Abstract Details 

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[Study on the detection of inv(16) in acute myelomonocytic leukemia (M4) by flucorescence in situ hybridization method] Abstract Text:

Ying Cai,Jing-Hua Wang,Jian Zhang,Juan-Hua Shi,Xi Jin,

To study the clinical significance of the detection of inv(16) (p13 q22) by FISH in the diagnosis and prognosis for M(4), the metaphase bone marrow cells of 6 cases M(4) which had already diagnosed by morphology were detected for CBFbeta-MYH(11) fusion gene by MYH 11 probe including dual labelled sequences and the results were compared with that of conventional cytogenetic analysis. The results showed that 4 cases inv(16) (two M(4) EO and two M(4)) were found by G banding kanyotyping test. One case M(4) had trisomy (+22) in addition to inv(16); one case M(4) had hypodiploid in addition to inv(16), which relapsed after CR 8 months. All 6 cases had inv(16) abnormal fluorescence signal. Among them case No 2 had the deletion of 16p13 showed by red fluorescence signal in addition to inv(16). It is concluded that the detection of inv(16) by FISH is of sensitivity and specificity. It is the important supplement to the conventional cytogenetic analysis. It possesses the important clinical significance in the diagnosis and prognosis of M(4) patients.

[Study on the detection of inv(16) in acute myelomonocytic leukemia (M4) by flucorescence in situ hybridization method] Publishing Authors By Initials

Y Cai,JH Wang,J Zhang,JH Shi,X Jin,

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[Study on the detection of inv(16) in acute myelomonocytic leukemia (M4) by flucorescence in situ hybridization method] Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Zhongguo shi yan xue ye xue za zhi / Zhongguo bing

VOLUME: 12

Page Numbers: 748-51

Journal Abbreviation: Zhongguo Shi Yan Xue Ye Xue Za

ISSN: 1009-2137

DAY: 5

MONTH: Dec

YEAR: 2004

[Study on the detection of inv(16) in acute myelomonocytic leukemia (M4) by flucorescence in situ hybridization method] Information

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LANGUAGE: chi

NlmUniqueID: 101084424

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Grant and Affiliation Information for [Study on the detection of inv(16) in acute myelomonocytic leukemia (M4) by flucorescence in situ hybridization method]

AFFILIATION: The Second Affiliated Hospital, Harbin Medical University, Harbin 150086, China.

Country: China

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MEDLINETA: Zhongguo Shi Yan Xue Ye Xue Za

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