[Study on the collagen constitution of hyperplastic scar in different ages and its influencing factors]

[Study on the collagen constitution of hyperplastic scar in different ages and its influencing factors] Research Abstract Details 

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[Study on the collagen constitution of hyperplastic scar in different ages and its influencing factors] Abstract Text:

Lin Qiu,Xian-qing Jin,Dai-li Xiang,Yue-xian Fu,Xiao-fei Tian,

OBJECTIVE: To investigate the collagen constitution of hyperplastic scar (HS) in different ages and the change of relative factors. METHODS: Thirty cases with HS were divided into two groups according to patients' age: group 1 (1 - 19 years, A) and group 2 (20 - 50 years, B). The normal skin (NS) from corresponding age of volunteers was employed as control group. The changes in TGFbeta1, collagenase (MMP-1) and tissue inhibitor of metalloproteinase (TIMP-1beta) and the collagen ratio were observed by means of in situ hybridization technique and SABC (Strept-Avidin-Biotin complex) immunohistochemistry and image analysis. RESULTS: The ratio of type I to type III collagen in A group was 6.48 in average and 3.76 in B group, but there was no evident difference in the ratio during the disease process in both groups. The expression of TGFbeta1 in A group was much higher than that in B group (P < 0.01). The TIMP-1 mRNA expression showed no difference among all age groups in HS patients, but it was much higher than that in NS group. The MMP-1 expression was evidently lower than TIMP-1 expression, and there was no difference in MMP-1 expression compared with NS group. CONCLUSION: (1) The TGFbeta1 expression in HS patients was negatively correlated with age, and the increased expression of TGFbeta1 produced an increase ratio of type I to type III collagen. (2) High level expression of TIMP-1 led to the formation of HS by inhibiting MMP-1 expression, and the expression was not related to age.

[Study on the collagen constitution of hyperplastic scar in different ages and its influencing factors] Publishing Authors By Initials

L Qiu,XQ Jin,DL Xiang,YX Fu,XF Tian,

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[Study on the collagen constitution of hyperplastic scar in different ages and its influencing factors] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua shao shang za zhi = Zhonghua shaoshang za

VOLUME: 19

Page Numbers: 236-40

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ISSN: 1009-2587

DAY: 29

MONTH: Aug

YEAR: 2003

[Study on the collagen constitution of hyperplastic scar in different ages and its influencing factors] Information

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LANGUAGE: chi

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Grant and Affiliation Information for [Study on the collagen constitution of hyperplastic scar in different ages and its influencing factors]

AFFILIATION: Department of Burns and Plastic Surgery, Children's Hospital, Chongqing University of Medical Science, Chongqing 400014, PR China.

Country: China

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MEDLINETA: Zhonghua Shao Shang Za Zhi

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